硬腭恶性肿瘤疗效评价和预后因素分析  

Effectiveness evaluation and prognostic factor analysis in patients with malignant tumor of the hard palate

作　　者：李铨[1] 刘学奎[1] 刘巍巍[1] 李浩[1] 郭朱明[1] 杨安奎[1] 张诠[1] 曾宗渊[1] 

机构地区：[1]华南肿瘤学国家重点实验室中山大学肿瘤防治中心头颈科,广东广州510060

出　　处：《中华肿瘤防治杂志》2010年第22期1840-1844,共5页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:分析硬腭恶性肿瘤的治疗效果及影响预后的因素。方法:对1964-2004年在中山大学肿瘤防治中心住院治疗的243例原发于硬腭的恶性肿瘤患者资料进行回顾性分析。应用Kaplan-Meier法计算累计生存率,各因素间比较用秩和对数(Log-rank)检验,多因素分析采用Cox模型。结果:243例患者总的5和10年生存率分别为45.91%和35.74%。单纯手术治疗103例和手术加放疗65例患者的5年生存率分别为60.07%和53.93%,10年生存率分别为52.80%和44.52%。多因素分析结果表明,手术切缘阳性、年龄≥50岁、颈淋巴结转移及肿瘤复发者预后差(P<0.05)。结论:手术治疗或以手术为主的综合治疗是硬腭恶性肿瘤的首选治疗方法。手术切缘情况、年龄、颈淋巴结转移及复发情况是影响硬腭恶性肿瘤患者预后的独立因素。OBJECTIVE：To evaluate the efficacy of treatment and investigate the prognostic factors of malignant tumor of the hard palate.METHODS：Totally 243 cases of malignant tumor of the hard palate hospitalized in Cancer Center,Sun Yat-sen University,from 1964 to 2004 were reviewed retrospectively.The cumulative survival rate was analyzed by Kaplan-Meier method.The prognostic factors were compared using the log-rank test.The influencing factors were screened by Cox proportional hazards model.RESULTS：The 5-and 10-year overall survival rates were 45.91% and 35.74%,respectively.The 5-and 10-year disease-specific survival rates for the patients treated with surgery（103 cases） and surgery ＋radiotherapy（65 cases） were 63.07%,52.80% and 53.93%,44.52%,respectively.Multivariate analysis showed that surgical margin status,age ≥50 years old,cervical metastasis and recurrence were independently associated with decrease survival rates（P0.05）.CONCLUSIONS：Surgery and surgery dominated multi-modality therapy are the principal modality of treatment for malignant tumor of the hard palate.Surgical margin status,age,cervical metastasis and recurrence are independent factors affecting the prognosis.

关 键 词：硬腭 恶性肿瘤 综合治疗 预后 回顾性研究 

分 类 号：R739.83[医药卫生—肿瘤]