甲状腺癌组织VEGF和MMP-9及COX-2的表达及其临床意义  

Clinical significance and expressions of vascular endothelial growth factor,matrix metalloproteinase-9 and cyclooxygenase-2 in human thyroid carcinoma

作　　者：张杰[1] 许俊龙[1] 张学东[1] 贾爱华[1] 鲁庆阳[1] 

机构地区：[1]聊城市人民医院病理科,山东聊城252000

出　　处：《中华肿瘤防治杂志》2010年第23期1924-1926,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)及环氧化酶-2(COX-2)在甲状腺癌组织中的表达情况及其与临床特征的关系。方法:SP法检测100例甲状腺癌及20例癌旁正常甲状腺组织中VEGF、MMP-9及COX-2的表达。观察其与患者临床病理及预后的关系。结果:甲状腺癌组织中,VEGF、MMP-9和COX-2的阳性率分别为70%(70/100)、68%(68/100)和63%(63/100),显著高于癌旁组织,P<0.01;三者阳性率高低与甲状腺癌的临床分期和淋巴结转移密切相关,P<0.01;VEGF、COX-2的阳性表达与甲状腺癌的组织类型有关,P<0.05。结论:甲状腺癌组织VEGF、MMP-9及COX-2的表达与临床分期及淋巴结转移有关,可作为甲状腺癌患者的预后指标。OBJECTIVE：To investigate the correlation between the expression of vascular endothelial cell growth factor（VEGF）,matrix metalloproteinase-9（MMP-9）,cyclooxygenase-2（COX-2） and histological clinical stage,lymph node metastasis in thyroid carcinoma.METHODS：The SP immunohistochemistry method was employed to determine the expressions of VEGF,MMP-9 and COX-2 in 100 thyroid carcinoma and 20 para-tumorous tissues.The relationship was observed with its clinical pathology and prognosis.RESULTS： The expressions of VEGF,MMP-9 and COX-2 in thyroid carcinoma with the positive frequency of 70%（70/100）,68%（68/100）and 63%（63/100） successively were significantly higher than those in para-tumorous tissues（P0.01）,which was correlated with the clinical stage and lymph node metastasis（P0.01）.The expressions of VEGF and COX-2 were associated with the histological feature of thyroid carcinoma（P0.05）.CONCLUSION： The expressions of VEGF,MMP-9 and COX-2 are associated with the clinical stage and metastasis of thyroid carcinoma,which may serve as prognosis indexes of thyroid carcinoma.

关 键 词：甲状腺肿瘤 受体 血管内皮生长因子 明胶酶 前列腺素内过氧化物合酶 

分 类 号：R736.1[医药卫生—肿瘤]