食管癌放疗中复方苦参联合地塞米松的应用  

Application of compound snphora angustifolia injection combined with dexamethasone in radiotherapy for esophageal carcinoma

作　　者：何晓军[1] 丁华[1] 倪峰[1] 

机构地区：[1]南通大学附属肿瘤医院放疗科,江苏南通226361

出　　处：《中华肿瘤防治杂志》2010年第23期1972-1973,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为了探讨复方苦参(岩舒注射液)联合地塞米松在食管癌放疗中的应用。81例食管癌放疗患者信封法随机分为2组。用药组,放疗DT20 Gy/10 f后予复方苦参联合地塞米松治疗,对照组予常规处理。用药组治疗有效率为82.9%(34/41),对照组为60.0%(24/40),差异有统计学意义,χ2=5.234,P=0.022。用药组与对照组急性放射性食管炎及气管炎发生率分别为〔31.7%(13/41)和57.5%(23/40),χ2=5.46,P=0.020〕和〔14.6%(6/41)和37.5%(15/40),χ2=5.51,P=0.019〕。两组治疗后1个月其急性放射性食管炎及气管炎发生率分别下降〔14.6%(6/41)和35.0%(14/40),χ2=4.52,P=0.034〕和〔12.2%(5/41)和32.5%(13/40),χ2=4.830,P=0.028〕。在提高生活质量方面(KPS评分),用药组提高率为65.9%(27/41),对照组42.5%(17/40),χ2=4.45,P=0.035。在减轻放射性肺纤维化等晚反应方面两组相似。初步研究结果提示,复方苦参联合地塞米松于食管癌放疗中,可提高近期疗效,减轻急性放射性食管炎及气管炎的发生,并明显缩短急性反应持续时间,提高患者生活质量。The objective of this study was to evaluate the effect of compound snphora angustifolia injection combined with dexamethasone in the treatment of patients with esophageal carcinoma by radiotherapy.Of the 81 patients with esophageal carcinoma by radiotherapy,41 were subjected to receive compound snphora angustifolia injection combined with dexamethasone and 40 were given the conventional treatment.The overall response rates（CR＋PR）were 82.9%（34/41） in the combination group and 60.0%（24/40） in the control group respectively.and there was a statistical difference（χ2=5.234,P=0.022）.The probabilities of acute esophagitis and trachitis were 31.7%（13/41）,14.6%（6/41） in the combination group and 57.5%（23/40）,37.5%（15/40） in the control group respectively,and there was a statistical difference（χ2=5.46,P=0.020;χ2=5.51,P=0.019）.The acute esophagitis and trachitis treated 1-month later were 14.6%（6/41）,12.2%（5/41） in the former and 35.0%（14/40）,32.5%（13/40） in the later respectively,and the differences were significant（χ2=4.52,P=0.034;χ2=4.830,P=0.028）.Those with KPS increasing were 65.9%（27/41） and 42.5%（17/40）,respectively,in the 2 groups,there was a statistical difference（χ2=4.45,P=0.035）.It was similar to the two groups in the late reaction to radioactive pulmonary fibrosis.In conclusions,the compound snphora angustifolia injection combined with dexamethasone for esophageal carcinoma can relieve acute reaction to radiotherapy,shorten the duration of the reaction,increase the overall response and Karnofsky performance scale.It was no value for the relief of late reaction to radioactive pulmonary fibrosis.

关 键 词：食管肿瘤 放射疗法 苦参 地塞米松 

分 类 号：R735.1[医药卫生—肿瘤]