盐酸帕洛诺司琼预防化疗所致恶心呕吐的临床观察  

Clinical trial of treating nausea and vomiting caused by chemotherapy with palonosetron

作　　者：盛桂凤[1] 毕延智[1] 曾冬香[1] 徐珍[1] 董益忠[1] 宋红蕾[1] 张亚平[1] 

机构地区：[1]苏州大学附属常州市肿瘤医院肿瘤内科,江苏常州213001

出　　处：《中华肿瘤防治杂志》2010年第23期1976-1977,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为了探讨盐酸帕洛诺司琼预防中重度化疗所致恶心和呕吐的疗效和安全性,采用随机对照的研究方法,研究组(32例)用药为盐酸帕洛诺司琼注射液,对照组(33例)用药为阿扎司琼注射液。对化疗后恶心止吐疗效进行评价。研究组和对照组对急性呕吐的控制率分别为78.1%(25/32)和78.8%(26/33),2组差异无统计学意义,P>0.05;而对于迟发性呕吐,帕洛诺司琼注射液优于阿扎司琼,P<0.05。盐酸帕洛诺司琼注射液的毒副反应主要为便秘。初步研究结果提示,盐酸帕洛诺司琼注射液能够预防化疗引起的急性和迟发性恶心、呕吐,疗效和安全性较好。The objective of this study was to investigate the efficacy and safety of palonosetron hydrochloride in prevention of nausea and vomit induced by chemotherapy.All cases were randomly divided into two groups,32 cases in a study group（treated with palonosetron） and 33 cases in a control group（treated with azasetron）.Response rates of prevention of acute vomit were 78.1%（25/32） and 78.8%（26/33） in two groups（P0.05）,while palonosetron was superior to azasetron in the prevention of chronic vomit（P0.05）.Only a few patients in two groups appeared slight constipation.In conclusion,palonosetron hydrochloride is effective and safe for prevention of nausea and vomit induced by chemotherapy.

关 键 词：肿瘤 药物疗法 化学预防 恶心 呕吐 

分 类 号：R730.5[医药卫生—肿瘤]