大鼠正畸牙移动过程中牙周组织内转化生长因子β_1的变化  

The changes of transforming growth factor beta 1 in periodontal tissue during orthodontic tooth movement

作　　者：汪玲丽[1] 朱虹[1] 梁傥[1] 

机构地区：[1]白求恩医科大学口腔医学院,长春130041

出　　处：《中华口腔医学杂志》1999年第4期242-244,共3页Chinese Journal of Stomatology

摘　　要：目的　了解大鼠正畸牙移动过程中转化生长因子β1(transforminggrowthfactorβ1,TGFβ1)在牙周组织内的变化,探讨TGFβ1在正畸牙移动过程中的作用。方法　对大鼠正畸牙移动不同阶段的牙及牙周组织联合切片,进行免疫组织化学研究。结果　正畸牙移动过程中,牙周膜内TGFβ1表达增加。加力第5～10天,张力区TGFβ1表达增加的幅度明显大于压力区。结论　TGFβ1在正畸牙移动的牙周组织改建中起重要作用。Objective To observe the distribution and change of transforming growth factor beta 1 (TGF β 1) in periodontal tissue and understand the role of TGF β 1 in orthodontic tooth movement. Methods Apply force on right maxillary first molars in rats, and examine the decalcified alveolodental connected tissue in different stage of tooth movement with immunohistochemical staining technique (SP method). Results TGF β 1 exists in normal periodontal tissue. The expression of it in periodontium increases during orthodontic tooth movement. Especially from 5 to 10 days after force application, the expression at tension side is much more than those at pressure side. Conclusion TGF β 1 plays an important role in remodeling of periodontal tissue during orthodontic tooth movement, and can powerfully promote bone formation.

关 键 词：免疫组织化学 牙移动 TGF-Β1 正畸牙 

分 类 号：R783.5[医药卫生—口腔医学]