加兰他敏与吡拉西坦治疗老年性痴呆和良性衰老性遗忘症的比较  

Galantamine vs piracetam in treatment of senile dementia and benign senescent forgetfulness

作　　者：薛寿儒[1] 张正春[1] 吴爱勤[2] 王金华[2] 

机构地区：[1]苏州医学院附属第一医院神经科,江苏苏州215006 [2]苏州医学院附属第一医院精神科,江苏苏州215006

出　　处：《中国新药与临床杂志》1999年第4期198-200,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的：评估加兰他敏胶囊治疗老年性痴呆和单纯性记忆障碍的疗效。方法：４２ 例老年性痴呆和３２ 例单纯性记忆障碍病人入组，其中３７ 例（ 男性２２例，女性１５ 例，年龄６３ ａ ±ｓ ８ ａ） 用加兰他敏胶囊１０ ｍ ｇ ，ｐｏ ，ｑｉｄ ，另３７ 例（ 男性２２ 例，女性１５ 例，年龄６５ ａ ±７ ａ） 用吡拉西坦胶囊８００ ｍ ｇ ，ｐｏ ，ｔｉｄ ，疗程均为８ ｗ ｋ 。结果：加兰他敏组总有效率７０ ％ ，吡拉西坦组为４０ ％ （ Ｐ＜ ０ ．０１） ，加兰他敏组痴呆病人日 常生活功能也较治疗前有明显提高（ Ｐ＜ ０ ．０１） ，该药不良反应轻。结论：加兰他敏胶囊治疗老年性痴呆安全有效。AIM: To evaluate the therapeutic effects of galantamine on senile dementia and benign senescent forgetfulness. METHODS: Thirty_seven patients with senile dementia and benign senescent forgetfulness in treatment group(M22, F 15, age 63 a±s 8 a) were treated with galantamine 10 mg, po, qid for 8 wk; other 37 patients (M 22, F 15,age 65 a±7 a) were treated with piracetam 800 mg, po, tid. RESULTS: The total effective rates of galantamine and piracetam were 70% and 40%, respectively(P<0.01). Daily life function of patients with senile dementia was improved after galantamine treatment. Adverse reactions of galantamine was mild. CONCLUSION:Galantamine has a safe and therapeutic effect on senile dementia.

关 键 词：加兰他敏 毗拉西坦 老年性痴呆 治疗 

分 类 号：R749.160.5[医药卫生—神经病学与精神病学]