熄风康对大鼠脑缺血保护作用  

The Protective Effects of XFK on Cerebral Ischimia Rats

作　　者：于树玲[1,2,3] 武继彪[1,2,3] 曹晓岚 

机构地区：[1]山东省胸科医院 [2]山东省中医药研究所 [3]山东中医药大学附属医院

出　　处：《时珍国医国药》1999年第8期561-562,共2页Lishizhen Medicine and Materia Medica Research

基　　金：山东省"八五"攻关课题

摘　　要：实验制作大鼠右侧颈总Ａ结扎脑缺血模型，观察了熄风康的保护作用。结果表明，熄风康能明显减轻大鼠神经细胞水肿，降低其脑组织含水量；明显升高脑缺血大鼠ｔＰＡ，降低ＰＡＩ；抑制ＶＷＦ生成，降低ＲＢＣ聚集指数，增加ＡＴ－Ⅲ活性；对大鼠实验性脑缺血有明显的保护作用。提示熄风康具有明显的防止血栓形成及减轻脑缺血性损伤的作用。The protective effects of Xi Feng Kang (XFK) were studied in cerebral ischimia rats induced by ligaturing right common carotid artery. The results indicated that XFK could significantly reduce edema of brain tissue cells, enhance tPA and AT-Ⅲ activity, decrease PAI, vWF and RBC aggregation index of cerebral ischimia rats, significantly protect the experimental cerebral ischimia rats. The study prompted that the drug has the function of preventing cerebral thromloosis and reducing the injury of cerebral ischimia.

关 键 词：熄风康 脑缺血 TPA PAI VWF AT-Ⅲ 

分 类 号：R285.5[医药卫生—中药学]