E-Cadherin、β-catenin蛋白在肾透明细胞癌中的表达及临床意义  

Expression and Clinical Significance of E-cadherin and β-catenin in Renal Clear Cell Carcinoma

作　　者：李飞宇[1] 李培军[2] 马良宏[2] 马爱玲[3] 秦璟[3] 

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学附属医院泌尿外科,银川750004 [3]宁夏医科大学附属医院病理科,银川750004

出　　处：《宁夏医科大学学报》2011年第3期249-252,F0003,共5页Journal of Ningxia Medical University

摘　　要：目的探讨E-Cadherin、β-catenin蛋白在肾透明细胞癌(RCCC)组织中的表达及临床意义。方法应用免疫组化方法对62例肾透明细胞癌和10例正常肾组织进行E-Cadherin、β-catenin蛋白检测。结果 RCCC组织中,E-Cadherin、β-catenin蛋白异常表达率分别为67.7%(42/62)和77.4%(48/62),二者表达之间具有显著相关性(P<0.01)。E-Cadherin、β-catenin蛋白的异常表达与RCCC病理分级和临床分期呈正相关(P<0.05)。E-Cadherin、β-catenin蛋白的异常表达在侵袭转移组和非侵袭转移组之间差异有统计学意义(P<0.05)。结论 E-Cadherin、β-catenin蛋白低表达或异常表达与肾透明细胞癌的分化、恶性程度有关,并对肾透明细胞癌预后评价有一定参考意义。Objective To investigate the expression and clinical significance of E-Cadherin and β-catenin in renal clear cell carcinoma（RCCC）.Methods The expression of E-Cadherin、β-catenin proteins in 62 cases of RCCC tissue and 10 normal renal tissue samples were analyzed by immunohistochemistry staining.Results The abnormal expression rates of E-Cadherin、β-catenin in RCCC were 67.7%（42/62）and 77.4%（48/62） respectively.The expression of E-Cadherin、β-catenin was significantly positively related with clinical stage and pathological grade of RCCC（P0.01）.The abnormal rate of E-Cadherin、β-catenin was associated with the invasion and metastasis（P0.05）.Conclusion The lower expression of E-Cadherin and β-catenin in renal clear cell carcinoma（RCCC） are related with the differentiation and malignancy and they may serve as a marker for assessing the clinical stage,pathological grade and progression of renal cell carcinoma.Determination of E-Cadherin andβ-catenin plays an important role in predicting tumor invasion.

关 键 词：肾透明细胞癌 免疫组化 E-CADHERIN Β-CATENIN 

分 类 号：R737.11[医药卫生—肿瘤]