VEGF抗体对骨肉瘤OS-732血管生成的抑制作用  

Inhibitory effects of antibody against vascular endothelial growth factor on angiogenesis induced by OS-732

作　　者：李颖嘉 王东[1] 高奉浔[1] 陈俐[1] 

机构地区：[1]第三军医大学附属大坪医院野战外科研究所病理科,重庆400042

出　　处：《第三军医大学学报》1999年第7期495-498,共4页Journal of Third Military Medical University

基　　金：全军"九五"青年基金!96Q074

摘　　要：目的：研究血管内皮生长因子（VascularendothelialgrowthfactorVEGF）抗体的抗骨肉瘤血管生成作用。方法：应用鸡胚尿囊膜（ChickembryoChorioallantoicmembrane，CAM）模型观察VEGF抗体对骨肉瘤血管生成及肿瘤生长的影响。结果：VEGF抗体组血管数目在给予抗体后第2、4、6、8天均显著低于PBS对照组（P＜0．05或P＜0．01），光镜下瘤细胞减少，新生血管腔减少。结论：VEGF抗体对骨肉瘤治疗具有良好的应用前景。Objective: To investigate the inhibitory effects of antibody against vascular endothelialgrowth factor (VEGF) on angiogenesis induced by OS-732. Methods: After the tumor model was establishedon the chick embryo chorioallantic membrane the effects of a polyclonal antibody against VEGF on angiogenesis and tumor growth were examined. Results: The number of the newly formed vessels upon the tumor wassignificantly decreased in the anti-VEGF antibody group as compared with the PBS control group on days 2,4, 6 and 8 after the anti-VEGF antibody was given (P＜0.05 or 0. 01 ). Optical microscopy showed the decrease in the tumor population and newly formed vessels. Conclusion: The anti-VEGF antibody may be potentially useful for clinical treatment of osteosarcoma.

关 键 词：血管内皮 生长因子 骨肉瘤 抗体 OS-732 

分 类 号：R738.1[医药卫生—肿瘤] R392.11[医药卫生—临床医学]