农村成年居民幽门螺杆菌感染的血清流行病学调查  

Seroepidemiological study on Helicobactor pylori infection in rural adult residents

作　　者：张祥宏[1] 孙旭明[1] 赵文元[1] 严霞[1] 王俊灵 张振国 米建民 谢同欣[1] 王会艳[1] 三角顺一 青木一雄 

机构地区：[1]河北医科大学病理研究室,石家庄050017 [2]赞皇县医院 [3]日本大分医科大学

出　　处：《中华流行病学杂志》1999年第4期212-214,共3页Chinese Journal of Epidemiology

摘　　要：目的　探讨农村成年居民幽门螺杆菌（Ｈｐ） 感染情况及其与血清胃蛋白酶原Ⅰ（ＰＧⅠ） 、胃蛋白酶原Ⅱ（ＰＧⅡ） 和胃泌素（ＧＡＳ） 水平的关系。方法　以ＥＬＩＳＡ 方法对赞皇县１ ５０４ 名３０岁以上居民血清Ｈｐ 抗体进行了检测，同时以放射免疫学方法对该组调查对象血清ＰＧⅠ、ＰＧⅡ、ＰＧⅠ／ＰＧⅡ比值和ＧＡＳ水平进行了定量分析。结果　赞皇县农村成年居民血清Ｈｐ 抗体阳性率为６６．４％ ，在性别之间阳性率差异无显著性。在不同年龄组的居民中，３０ ～５０ 岁和７０ 岁以上组血清Ｈｐ 抗体阳性率有增高趋势，但统计学意义不明显。胃癌高发区和相对低发区居民血清Ｈｐ 抗体阳性率差异不明显。血清Ｈｐ ＩｇＧ抗体阳性居民血清ＰＧⅠ、ＰＧⅡ和ＧＡＳ水平（６２ ．３μｇ／Ｌ，１５ ．４５μｇ／Ｌ，７４．００ｐｇ／ｍｌ） 均明显高于ＨｐＩｇＧ抗体阴性者（４２ ．１μｇ／Ｌ，６ ．４０μｇ／Ｌ，６６．００ｐｇ／ｍｌ） ，Ｐ＜ ０．００５ ，而血清ＰＧⅠ／ＰＧⅡ比值则显著低于后者（４．０∶６．６ ，Ｐ＜ ０．００５） 。结论　赞皇县大部分农村成年居民有Ｈｐ 感染；Ｈｐ 感染可影响血清ＰＧ和ＧＡＳ水平。Objective To study the prevalence of Helicobactor pylori (Hp) infection in rural adult residents of China and its relation to serum levels of pepsinogen Ⅰ (PGⅠ),pepsinogen Ⅱ (PGⅡ) and gastrin (GAS). Methods Serum levels of antibodies against Hp were determined with enzyme-liked immunosorbent assay (ELISA) in 1 504 residents aged over 30 in Zanhuang County of Hebei Province, and their serum levels of PGⅠ,PGⅡ and GAS, as well as PGⅠ/PGⅡ ratio,were analyzed quantitatively, with radioimmunoassay (RIA). Results Positivity for serum Hp antibody accounted for 66.4 % of the rural adults in Zanhuang County, without significant sex difference. There was no significant difference in positivity for serum Hp antibody between residents in the high and low prevalent areas of gastric cancer. Serum levels of PGⅠ,PGⅡ and GAS were significantly higher in those with positive serum IgG anti-Hp ( 62.3 μg/L, 15.45 μg/L and 74.00 pg/ml, respectively) than those negative ( 42.1 μg/L, 6.40 μg/L and 66.00 pg/ml, respectively), all with a P-value less than 0.005, and the ratio of serum PGⅠ to PGⅡ levels was significantly lower in the former (4.0) than that in the latter (6.6), with P <0.005. Conclusion More than two thirds of the adult residents in Zanhuang County had infected with Hp,which could affect their serum levels of PG and GAS.

关 键 词：幽门螺杆菌 血清流行病学 胃蛋白酶原 胃泌素 

分 类 号：R573.01[医药卫生—消化系统] R181.36[医药卫生—内科学]