血清游离雌三醇和胎盘催乳素联合测定在孕产妇监护中的意义  

Clinical Significance of Combined Measurement of Maternal Serum Free Estriol and Human Lactogen in Pregnant Women

作　　者：朱庆文[1] 周君[1] 

机构地区：[1]南通市妇幼保健院,江苏南通226006

出　　处：《标记免疫分析与临床》2011年第2期74-76,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨血清游离雌三醇(FE3)和胎盘催乳素(HPL)联合测定诊断胎儿在宫内的生长发育情况。FE3采用化学发光法,HPL采用放射免疫分析(RIA)测定。妊娠合并高血压综合征,胎儿宫内窘迫FE3、HPL含量均比正常妊娠组低(P<0.05);孕妇如有先兆流产,HPL值将连续下降,当HPL<4mg/L时,流产不可避免;妊娠合并糖尿病孕妇的FE3和HPL值与正常妊娠组相比差异无统计学意义(P>0.05)。FE3和HPL联合测定能判断胎儿-胎盘功能低下和提高高危妊娠的诊断率,对快速诊断胎盘功能及胎儿发育迟缓等疾病有一定的临床意义。To evaluate the clinical significance of combined measurement of maternal serum free estriol（FE3） and human lactogen（HPL） for determination of intrauterine fetal growth and development.The serum FE3 and HPL in pregnant women were measured by chemiluminescence and RIA respectively.The results showed that the E3 and HPL levels in pregnant women with pregnancy induced hypertension were lower than the normal controls（P0.05）.The HPL levels in threatened pregnant women was continuous decrease.The abortion was unavoidable when the HPL level was less than 4mg/L.There was no statistical significance on E3 and HPL levels between pregnant women with diabetes and normal controls（P0.05）.The combined measurement of maternal serum free estriol and human lactogen has important clinical significance in determination of fetus-placenta function and high risk pregnancy.

关 键 词：胎盘催乳素 游离雌三醇 孕妇 

分 类 号：R714.25[医药卫生—妇产科学] R714.57[医药卫生—临床医学]