CD133和Oct4在喉癌中的表达及临床意义  

Expression of CD133 and Oct4 in laryngeal carcinoma and their clinical significance

作　　者：王孝[1] 田军[2] 张金龙[1] 刘守洲[1] 

机构地区：[1]潍坊医学院耳鼻喉科教研室,山东潍坊261053 [2]潍坊市人民医院耳鼻喉科,山东潍坊261041

出　　处：《现代医药卫生》2011年第8期1125-1127,共3页Journal of Modern Medicine & Health

摘　　要：目的:探讨CD133和Oct4在喉癌中的表达及与喉癌临床病理学特征之间的关系。方法:利用免疫组织化学方法检测56例喉癌组织及10例癌旁正常组织中CD133和Oct4的表达,比较二者的表达与临床病理参数之间的相关性。结果:CD133和Oct4在喉癌组织内表达阳性率分别为69.6%、25.0%,均明显高于正常组织;CD133与Oct4在中、低分化喉癌组织内表达均高于高分化者(P<0.05);CD133的表达与喉癌的TNM分期和淋巴结转移具有相关性(P<0.05),而与患者的年龄、性别和肿瘤生长部位无相关性,Oct4的表达与以上因素均无相关性;二者在喉癌组织中的表达呈正相关。结论:CD133和Oct4可共同作为喉癌的肿瘤干细胞标志物,作为喉癌恶性程度的判断指标;CD133的表达在喉癌发生、发展及转移中发挥重要作用,为喉癌的诊断和治疗提供依据;Oct4与喉癌的关系有待进一步研究证明。Objective：To explore the change of serum sCD40L levels in the patients with obstructive sleep apnea hypopnea syndrome（OSAHS） complicating coronary artery disease（CAD） and to further understand the mechanism of OSASH complicating CAD.Methods： 111 patients were checked serum sCD40L.21 normal cases were treated as the control group.22 patients with CAD were treated as the CAD group.33 cases of OSAHS were treated as the OSAHS group,and were subdivided into mild,moderate and severe three subgroups according to AHI. The other 35 cases of OSAHS complicating CAD,as the OSAHS＋CAD group,were subdivided into three subgroups like the OSAHS group. The patients with severe OSAHS were applied nCPAP treatment for three months,and took PSG test and blood test again.Results：Serum levels of sCD40L in the patients with OSAHS and CAD were much higher than that in the control group （P〈0.01）.The serum levels of sCD40L in the OSAHS patients complicating CAD were higher than those in the patients with CAD and OSAHS （P〈0.01）.The levels of sCD40L was raised up with the increase of severity of OSAHS complicating CAD. The level of sCD40L in the severe OSAHS patients was descended after 3-month CPAP treatment.Conclnslon：sCD40L can be as an evaluation index of the severity of OSAHS,which has significance to predict OSAHS complicating CAD.CPAP treatment may delay the progression of OSAHS complicating CAD.

关 键 词：喉癌 肿瘤干细胞 CD133 OCT4 免疫组化 

分 类 号：R73[医药卫生—肿瘤]