多发性骨髓瘤与MHC-DRB1~＊基因的相关研究  

MHC-DRB1~＊ gene polymorphism in patients with Multiple myeloma

作　　者：殷石 宋洪利 付瑜 蔡航 曹峰林[2] 马心慧 王双力 武伟晶 

机构地区：[1]黑龙江省武警总队医院,哈尔滨150076 [2]哈尔滨医科大学附属第一医院,哈尔滨150010

出　　处：《中国优生与遗传杂志》2011年第5期25-26,28,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨北方地区汉族人多发性骨髓瘤(MM)与人类主要组织相容性复合体MHC-DRB1*基因多态性的关系。方法应用顺序特异性引物和聚合酶链反应(PCR-SSP)技术,对21例多发性骨髓瘤患者及32例无血缘关系的健康人的MHC-DRB1*各等位基因及亚基因进行了检测分析,并将该方法与其它检测MHC等位基因的方法进行对比。结果结果表明,MHC-DRB1*11(RR=2.36,P<0.05;MHC-DRB1*11基因与MM呈正相关,显著高于对照组,两组之间比较差异有显著性意义,而其它MHC-DRB1*各等位基因未见异常,均无统计学差异。结论本项研究结果提示,MHC-DRB1*11基因可能是我国北方汉族人MM致病的易感基因,为揭示MM的发病机制中免疫遗传学作用提供了重要信息和依据。Objective：In order to study the correlativity between MHC-DRB1＊gene polymorphism and Multiple myeloma,（MM）.Methods： MHC-DRB1＊gene Polymorphism in 21 patients with MM and 32 normal control subjects was analyzed by using the polymerease chain reaction／sequence specific primer（PCR／SSP）technique.Result：MHC-DRB1＊11（RR=2.36,P〈0.05）.The frequency of MHC-DRB1＊11 allele was significantly higher in patients than that in the controls.Conclusion：These findings further Verify that immunogenetics play a predominant Pathogenetics role in a subset of MM patients.Individuals carrying MHC-DRB1＊11 alleles may be susceptibility gene to MM.This method is more specific,sensitive,simple,rapid and accurate,and could be applied to the routine clinical detective.

关 键 词：多发性骨髓瘤(MM) 人类主要组织相容性复合体(MHC) 基因多态性 

分 类 号：R733.3[医药卫生—肿瘤]