胎儿超声软标记在染色体异常产前筛查中的临床意义及预后分析  

The clinical significance and prognosis of fetal ultrasonic soft markers in prenatal screening of chromosome abnormality

作　　者：苗明珠[1] 孙丽洲[1] 姜海风[1] 王珏[1] 卢守莲[1] 

机构地区：[1]南京医科大学第一附属医院妇产科,南京210036

出　　处：《中国优生与遗传杂志》2011年第5期42-45,共4页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨胎儿超声软标记在染色体异常产前筛查中的临床意义及其预后。方法研究对象为2007年5月～2009年5月期间在我院进行产前超声检查的12850例孕妇,为非选择性病例。统计超声软标记阳性的孕妇,并分析其胎儿转归及染色体检查情况。结果共检出超声软标记阳性的孕妇628例(48.87‰)。628例孕妇中继续妊娠至分娩者488例(77.71%),引产12例(1.91%),失访128例(20.38%)。孕期行胎儿染色体检查者25例,正常核型25例,异常0例。胎儿染色体检查率3.98%,染色体异常率0%。结论超声软标记可作为调整染色体异常基础风险的一种非侵入性的方法。超声检查发现软标记阳性者,应该立即由经验丰富的超声医生对胎儿进行更详细的超声检查。产前筛查中需加强咨询指导,减少不必要的侵入性检查及引产。Objective： To investigate the clinical significance and prognosis of fetal ultrasonic soft markers in prenatal screening of chromosome abnormality.Methods： This study recruited 12850 pregnant women who underwent prenatal ultrasonic scan in our hospital between May 2007 to May 2009.All patients were unselected.Analyze the pregnant women whose soft markers were positive.The prognosis and karyotype of fetuses were assessed.Results： There were 628 cases whose soft markers were positive.Of 628 cases assessed,488 cases（77.71%）delivered,12 cases（1.91%）aborted,128 cases（20.38%）were missed.25 cases underwent karyotyping,and all 25 cases were normal karyotype.The rate of karyotyping was 3.98%.Conclusions： As a noninvasive approach,ultrasonic soft markers can be used to adjust the priori risk of chromosome abnormality.To the cases with positive soft markers,a detailed ultrasound scan should be conducted by an expertise sonographer.After prenatal screening,Consultant should be strengthened to avoid unnecessary invasive procedure and abortion.

关 键 词：超声 软标记 染色体异常 产前筛查 

分 类 号：R445.12[医药卫生—影像医学与核医学]