Protein folding, protein homeostasis,and cancer  

作　　者：John H. Van Drie 

机构地区：[1]Van Drie Research

出　　处：《Chinese Journal of Cancer》2011年第2期124-137,共14页

摘　　要：Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperones. Protein folding is an ongoing cellular process, as cellular proteins constantly undergo synthesis and degradation. Here emerging links between this process and cancer are reviewed. This perspective both yields insights into the current struggle to develop novel cancer chemotherapeutics and has implications for future chemotherapy discovery.Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperones. Protein folding is an ongoing cellular process, as cellular proteins constantly undergo synthesis and degradation. Here emerging links between this process and cancer are reviewed. This perspective both yields insights into the current struggle to develop novel cancer chemotherapeutics and has implications for future chemotherapy discovery.

关 键 词：蛋白质折叠 蛋白质平衡 癌症 化疗药物 氨基酸序列 三维结构 蛋白合成 细胞 

分 类 号：R730.5[医药卫生—肿瘤]