Lysine methylation of promoter-bound transcription factors and relevance to cancer  

作　　者：George R Stark Yuxin Wang Tao Lu 

机构地区：[1]Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA [2]Institute of Cancer Biology and Drug Screening, School of Life Science, Lanzhou University, Lanzhou 730000, China

出　　处：《Cell Research》2011年第3期375-380,共6页细胞研究（英文版）

摘　　要：p53, NFKB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NFKB and STAT3 take place when they are bound to promoters, suggesting a more general model in which the binding of inducible transcription factors to DNA helps to recruit chromatin-modification machinery, which then may modify not only histones but also the bound transcription factors. Mutations of some histone-lysine methyltransferases and demethylases are linked to cancer, and these mutations may alter the methylation not only of histones but also of transcription factors, and thus may be tumorigenic through more than one mechanism.

关 键 词：posttranslational modification HISTONES transcription factors 

分 类 号：Q783.1[生物学—分子生物学] S852.2[农业科学—基础兽医学]