HISTONES

作品数：39被引量：87H指数：5
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相关领域：生物学更多>>
相关机构：中国科学技术大学更多>>
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Liquid Liver Biopsy for Disease Diagnosis and Prognosis
《Journal of Clinical and Translational Hepatology》2023年第7期1520-1541,共22页Desislava K.Tsoneva Martin N.Ivanov Manlio Vinciguerra 
funded by the Ministry of Education and Science of Bulgaria under the National Scientific Program“Excellent Research and People for the Development of European Science”2021(VIHREN)of the Bulgarian National Science Fund,contract#KP-06-DV/4 from 15.12.2021;by the Bulgarian National Science Fund,contract#KP-06-N53/6 from 11.11.2021.
Liver diseases are a major burden worldwide,the scope of which is expected to further grow in the upcoming years.Clinically relevant liver dysfunction-related blood markers such as alanine aminotransferase and asparta...
关键词：Liquid biopsy Histones NAFLD/MAFLD Chronic liver disease Hepatocellular carcinoma 
Histones of Neutrophil Extracellular Traps Induce CD11b Expression in Brain Pericytes Via Dectin-1 after Traumatic Brain Injury被引量：1
《Neuroscience Bulletin》2022年第10期1199-1214,共16页Yang-Wuyue Liu Jingyu Zhang Wanda Bi Mi Zhou Jiabo Li Tiantian Xiong Nan Yang Li Zhao Xing Chen Yuanguo Zhou Wenhui He Teng Yang Hao Wang Lunshan Xu Shuang-Shuang Dai 
This work was supported by the National Natural Science Foundation of China(32000670 and 82071779);Chongqing Research Program of Basic Research and Frontier Technology(cstc2017jcyjAX0338).
The brain pericyte is a unique and indispensable part of the blood-brain barrier(BBB),and contributes to several pathological processes in traumatic brain injury(TBI).However,the cellular and molecular mechanisms by w...
关键词：PERICYTE NEUTROPHIL TBI NET DECTIN-1 
Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells被引量：2
《Cellular & Molecular Immunology》2022年第5期577-587,共11页Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei 
supported by the National Science Foundation for Excellent Young Scholars (32122052);National Natural Science Foundation Regional Innovation and Development (No.U19A2003).
Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expec...
关键词：COVID-19 SARS-CoV-2 neutrophil extracellular traps HISTONES sialic acid 
A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors
《Bioactive Materials》2022年第3期554-565,共12页Jianquan Guo Dongsheng Tan Chenmei Lou Shiying Guo Xing Jin Haijing Qu Lijia Jing Sijin Li 
This work was financially supported by National Natural Science Foundation of China(No.81701822);Heilongjiang Province Science Foundation for Youths(No.QC2018090);the Fundamental Research Funds for Central Universities(No.2572017PZ09);China Postdoctoral Science Foundation(No.2016M600238);Heilongjiang Postdoctoral Special Fund(No.LBH-TZ1601);Northeast Forestry University Double First-Rate Construction Fund(No.000/41113281).
Nanoparticle-based chemophotothermal therapy(CPT)is a promising treatment for multidrug resistant tumors.In this study,a drug nanococktail of DIR825@histone was developed by employing doxorubicin(DOX),NIR dye IR825 an...
关键词：Human histones Chemotherapy Photothermal therapy Nuclear targeting Localized intervention Drug resistant tumor 
Epigenetic regulation by long noncoding RNAs in osteo-/adipogenic differentiation of mesenchymal stromal cells and degenerative bone diseases被引量：4
《World Journal of Stem Cells》2022年第1期92-103,共12页Kai Xia Li-Yuan Yu Xin-Qi Huang Zhi-He Zhao Jun Liu 
the National Natural Science Foundation of China,No.81870743 and No.81771048.
Bone is a complex tissue that undergoes constant remodeling to maintain homeostasis,which requires coordinated multilineage differentiation and proper proliferation of mesenchymal stromal cells(MSCs).Mounting evidence...
关键词：Long noncoding RNA EPIGENETICS DNA methylation HISTONES Cell differentiation Bone diseases 
Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway被引量：7
《World Journal of Gastroenterology》2020年第47期7513-7527,共15页Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang 
Supported by Key R&D Program of Jiangsu Province,No.BE2019712;British Heart Foundation,No.PG/14/19/30751 and No.PG/16/65/32313.
BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms...
关键词：Liver fibrosis Extracellular histones Non-anticoagulant heparin TLR4 MYD88 CCL4 
In Lupus Erythematosus the Deposition of Immune Complexes in Tissues Is Mediated via Nuclear Histones Released by Neutrophils Nets but the Main Damage to Hosts Tissues Is Caused by the Plethora of Toxic Pro Inflammatory Agents Released by Activated Neutrophils—A Working Hypothesis
《Open Journal of Rheumatology and Autoimmune Diseases》2020年第2期79-87,共9页Isaac Ginsburg 
The present study offers a novel approach that may explain the mechanisms of pathogenicity of the auto immune destructive disorder, Lupus Erythematosus. It is proposed that deposition of immune complexes and complemen...
关键词：Auto Immune Destructive Disorder Lupus Erythematosus 
DFT Study, Linear and Nonlinear Multiple Regression in the Prediction of HDAC7 Inhibitory Activities on a Series of Hydroxamic Acids
《Computational Molecular Bioscience》2019年第3期63-80,共18页Doh Soro Lynda Ekou Bafétigué Ouattara Mamadou Guy-Richard Kone Tchirioua Ekou Nahossé Ziao 
In this work, we conducted a QSAR study on 18 molecules using descriptors from the Density Functional Theory (DFT) in order to predict the inhibitory activity of hydroxamic acids on histone deacetylase 7. This study i...
关键词：Hydroxamic ACIDS HISTONES DEACETYLASES DFT HISTONES DEACETYLASES Inhibitors QSAR 
Targeting histones for degradation in cancer cells as a novel strategy in cancer treatment被引量：2
《Science China(Life Sciences)》2019年第8期1078-1086,共9页Yesheng Yin Qianqian Zhu Tianxia Jiang Libin Fan Xiaobo Qiu 
supported by the National Natural Science Foundation of China (31530014, 91319303 & 31600626)
The anticancer therapies with the joint treatment of a histone deacetylase(HDAC) inhibitor and a DNA-damaging approach are actively under clinical investigations, but the underlying mechanism is unclear. Histone homeo...
关键词：HDAC HISTONE DEACETYLASE inhibitor DNA damage ANTICANCER agent HISTONE DEGRADATION 
A Peptidomic Analysis of the Potential Comorbidity Biomarkers for Type 2 Diabetes Mellitus and Alzheimer’s Disease
《Health》2019年第6期817-826,共10页Zhengqiang Du Jian Hua Dalin Song 
Objective: To investigate the potential comorbidity biomarkers for Type 2 Diabetes Mellitus (T2DM) and Alzheimer’s disease (AD). Methods: This is a randomized case-control study. There are three groups: 1) normal con...
关键词：Type 2 Diabetes MELLITUS (T2DM) Alzheimer’s Disease (AD) COMORBIDITY Biomarkers OSTEOPONTIN HISTONES 
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