Liquid Liver Biopsy for Disease Diagnosis and Prognosis  

作　　者：Desislava K.Tsoneva Martin N.Ivanov Manlio Vinciguerra 

机构地区：[1]Department of Medical Genetics,Medical University of Varna,Varna,Bulgaria [2]Department of Stem Cell Biology and Transplantology,Research Institute,Medical University of Varna,Varna,Bulgaria [3]Department of Anatomy and Cell Biology,Research Institute,Medical University of Varna,Varna,Bulgaria [4]Faculty of Health,Liverpool John Moores University,Liverpool,United Kingdom

出　　处：《Journal of Clinical and Translational Hepatology》2023年第7期1520-1541,共22页临床与转化肝病杂志（英文版）

基　　金：funded by the Ministry of Education and Science of Bulgaria under the National Scientific Program“Excellent Research and People for the Development of European Science”2021(VIHREN)of the Bulgarian National Science Fund,contract#KP-06-DV/4 from 15.12.2021;by the Bulgarian National Science Fund,contract#KP-06-N53/6 from 11.11.2021.

摘　　要：Liver diseases are a major burden worldwide,the scope of which is expected to further grow in the upcoming years.Clinically relevant liver dysfunction-related blood markers such as alanine aminotransferase and aspartate aminotransferase have limited accuracy.Nowadays,liver biopsy remains the gold standard for several liver-related pathologies,posing a risk of complication due to its invasive nature.Liquid biopsy is a minimally invasive approach,which has shown substantial potential in the diagnosis,prognosis,and monitoring of liver diseases by detecting disease-associated particles such as proteins and RNA molecules in biological fluids.Histones are the core components of the nucleosomes,regulating essential cellular processes,including gene expression and DNA repair.Following cell death or activation of immune cells,histones are released in the extracellular space and can be detected in circulation.Histones are stable in circulation,have a long half-life,and retain their post-translational modifications.Here,we provide an overview of the current research on histone-mediated liquid biopsy methods for liver diseases,with a focus on the most common detection methods.

关 键 词：Liquid biopsy Histones NAFLD/MAFLD Chronic liver disease Hepatocellular carcinoma 

分 类 号：R575[医药卫生—消化系统]