DEACETYLASE

作品数：49被引量：146H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：张春雷孙树汉周伟平王芳杨富更多>>
相关机构：第二军医大学桂林医学院桂林医学院附属医院北京大学第三医院更多>>
相关期刊：《Chinese Medical Journal》《Neuroimmunology and Neuroinflammation》《Advances in Microbiology》《实用休克杂志（中英文）》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划霍英东教育基金广西壮族自治区自然科学基金更多>>
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2-hydroxy-3-methyl anthraquinone promotes apoptosis and inhibits invasion of human hepatocellular carcinoma cells by targeting nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1/cellular tumor antigen p53 signaling pathway
《Journal of Traditional Chinese Medicine》2024年第6期1104-1110,共7页WU Shuang LI Qiao ZHU Xieying ZHANG Taoyuan 
Natural Science Basic Research Plan in Shannxi Province of China,the Intervention and Mechanism of Developmentalendotheliallocus-1 Regulating Macrophage Efferocytosis on Airway Inflammation in Chronic Obstructive Pulmonary Disease (No. 2020JQ-543);the Function and Mechanism of New Tumor Suppressor TSC22D2 in Cancer Glycometabolism (No. 2020JQ-927);Fundamental Research Funds for The Central University:the Role of TSC22D2-centered Protein Interaction Map in Cancer Glycometabolism and Cell Growth (No. xzy012019129)。
OBJECTIVE: To investigate the anti-liver cancer effect of 2-hydroxy-3-methyl anthraquinone(HMA) and the specific mechanism based on nicotinamide adenine dinucleotidedependent protein deacetylase sirtuin-1(SIRT1)/cellu...
关键词：2-hydroxy-3-methylanthraquinone carcinoma hepatocellular apoptosis INVASION sirtuin 1 genes p53 
The deacetylase SIRT2 contributes to autoimmune disease pathogenesis by modulating IL-17A and IL-2 transcription被引量：2
《Cellular & Molecular Immunology》2022年第6期738-750,共13页Ryo Hisada Nobuya Yoshida Masataka Umeda Catalina Burbano Rhea Bhargava Marc Scherlinger Michihito Kono Vasileios C.Kyttaris Suzanne Krishfield George C.Tsokos 
This work was supported by NIH grant R37 AI49954(to GCT);the Uehara memorial foundation(to RH);the 2019 Gilead Sciences Research Scholars Program in Rheumatology(to NY);the SociétéFrançaise de Rhumatologie,the Arthur-Sachs&Monahan fellowships and the Philippe Foundation(to MS).
Aberrant IL-17A expression together with reduced IL-2 production by effector CD4^(+)T cells contributes to the pathogenesis of systemic lupus erythematosus(SLE).Here,we report that Sirtuin 2(SIRT2),a member of the fam...
关键词：SIRT2 Systemic lupus erythematosus IL-17A IL-2 
Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis被引量：5
《Molecular Plant》2021年第11期1951-1960,共10页Arabidopsis Sera Choi Maxim Prokchorchik Hyeonjung Lee Ravi Gupta Yoonyoung Lee Eui-Hwan Chung Buhyeon Cho Min-Sung Kim Sun Tae Kim Kee Hoon Sohn 
This research was supported by Basic Science Research Programs through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2019R1I1A1A01060108);Korean government(MSIT)(NRF-2018R1A5A1023599 and NRF-2019R1A2C2084705)。
Plant pathogenic bacteria deliver effectors into plant cells to suppress immunity and promote pathogen survival;however, these effectors can be recognised by plant disease resistance (R) proteins to activate innate im...
关键词：Acetyltransferase effectors Effector-triggered immunity Immunity suppressors NLR Plant deacetylase Plant immunity 
Enhanced osteogenic differentiation of human periodontal ligament stem cells by suberoylanilide hydroxamic acid被引量：1
《BIOCELL》2020年第3期389-400,共12页YUNZE XUAN BIN JIN SAYAN DEB DUTTA MENGMENG LIU ZAIXIAN SHEN XIWEN LIU YANG KANGJUAN LIM KI-TAEK 
the National Research Foundation of Korea(NRF)and funded by the Ministry of Education(No.2018R1A6A1A03025582);the National Research Foundation of Korea(NRF-2019R1D1A3A03103828).
Periodontitis is a type of chronic inflammation in the gingival tissue caused by infectious bacteria colonizing the surface of the teeth,leading to the destruction of tooth-supporting tissues and loss of alveolar bone...
关键词：Suberoylanilide hydroxamic acid HISTONE DEACETYLASE OSTEOBLAST hPDLSCs ALKALINE PHOSPHATASE PERIODONTAL bone regeneration 
Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα被引量：6
《World Journal of Gastroenterology》2020年第18期2203-2220,共18页Feng-Zhi Xin Ze-Hua Zhao Rui-Nan Zhang Qin Pan Zi-Zhen Gong Chao Sun Jian-Gao Fan 
Supported by National Key R&D Program of China,No.2017YFC0908903;National Natural Science Foundation of China,No.81873565,No.81470840,and No.81700503.
BACKGROUND Folic acid has been shown to improve non-alcoholic steatohepatitis(NASH),but its roles in hepatic lipid metabolism,hepatic one-carbon metabolism,and gut microbiota are still unknown.AIM To demonstrate the r...
关键词：Nonalcoholic fatty liver disease Folic acid Gut microbiota PPARΑ SIRT1 
Class Ⅰ histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells被引量：6
《Acta Pharmaceutica Sinica B》2020年第4期615-627,共13页Baoyuan Zhang Junfang Lyu Eun Ju Yang Yifan Liu Changjie Wu Lakhansing Pardeshi Kaeling Tan Qiang Chen Xiaoling Xu Chu-Xia Deng Joong Sup Shim 
supported by the Multi-Year Research Grant of the University of Macao,China(MYRG2017-00176-FHS to Joong Sup Shim).
Breast cancer susceptibility gene 1(BRCA1)is a tumor suppressor gene,which is frequently mutated in breast and ovarian cancers.BRCA1 plays a key role in the homologous recombination directed DNA repair,allowing its de...
关键词：BRCA1 Histone DEACETYLASE HDAC SYNTHETIC LETHALITY Reactive oxygen species DNA damage Breast cancer 
Chidamide based combination regimen for treatment of monomorphic epitheliotropic intestinal T cell lymphoma following radical operation:Two case reports被引量：7
《World Journal of Clinical Cases》2020年第7期1278-1286,共9页Ting-Zhi Liu Yi-Jia Zheng Zhan-Wen Zhang Shan-Shan Li Jiao-Ting Chen Ai-Hua Peng Ren-Wei Huang 
BACKGROUND Monomorphic epitheliotropic intestinal T cell lymphoma(MEITL)is a rare extranodal T-cell lymphoma that has uniformly aggressive features with a poor prognosis.No standardized treatment protocols have been e...
关键词：Monomorphic epitheliotropic INTESTINAL T CELL lymphoma HISTONE DEACETYLASE inhibitor CHIDAMIDE Intensive chemotherapy Stem CELL transplantation Case report 
Role of Sulforaphane on Histone Deacetylase Activity in Solid Ehrlich Carcinoma
《Journal of Biosciences and Medicines》2020年第3期104-118,共15页Mai M. El-Keey Wafaa M. Ibrahim Mohamad A. El-Ghonamy Ehab Tousson Tarek M. Mohamed 
Histone acylation is one in every of the posttranslational modification that incorporates a role within the regulation of sequence expression. This study was aimed to ameliorate neoplasm cell model Solid Ehrlich malig...
关键词：HISTONE DEACETYLASE (HDAC) SULFORAPHANE (SFN) DNA Damage SOLID Ehrlich Carcinoma 
Epigenetic therapies in acute myeloid leukemia: the role of hypomethylating agents, histone deacetylase inhibitors and the combination of hypomethylating agents with histone deacetylase inhibitors被引量：6
《Chinese Medical Journal》2020年第6期699-715,共17页Qing-Yu Xu Li Yu 
This work was supported by grants from the National Natural Science Foundation of China(No.81670162,No.81970151,and No.81470010).
Epigenetic regulation includes changes of DNA methylation and modifications of histone proteins and is essential for normal physiologic functions,especially for controlling gene expression.Epigenetic dysregulation pla...
关键词：Acute MYELOID leukemia DECITABINE 5-AZACYTIDINE HISTONE DEACETYLASE inhibitors Intensive chemotherapy 
Neuroprotective mechanism of TMP269, a selective class ⅡA histone deacetylase inhibitor, after cerebral ischemia/reperfusion injury被引量：5
《Neural Regeneration Research》2020年第2期277-284,共8页Lu Su Dan Liang Shen-Yi Kuang Qiang Dong Xiang Han Zheng Wang 
supported by the National Natural Science Foundation of China,No.81501134(to ZW)
TMP269 is a selective class ⅡA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of ...
关键词：blood-brain barrier drug treatment ENDOTHELIAL cell permeability HISTONE DEACETYLASE inhibitor NEUROPROTECTION stroke tissue KALLIKREIN TMP269 
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