SULFORAPHANE

作品数：53被引量：217H指数：9
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The preventive mechanisms and research progress of sulforaphane in relation to prostate cancer
《BIOCELL》2024年第12期1703-1719,共17页HUANGLIN DUAN BAISHENG XU TIANPENG XIE 
Prostate cancer is one of the most common tumors in urology.Dietary prophylaxis can effectively reduce prostate cancer incidence and progression.A growing body of research has shown that natural food ingredients such ...
关键词：CANCER SULFORAPHANE Diet and cancer Sulforaphane prevention mechanism 
Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization
《Food Science and Human Wellness》2024年第5期2727-2740,共14页Xianghui Huang Jia Xu Ye Xu Bingxin Huangfu Feng Zhang Yanzhou Hu Ruxin Gao Xinxin Ren Boyang Zhang Kunlun Huang Xiaoyun He 
supported by the Science and Technology project of Henan Province(202102310142);the National Natural Science Foundation of China(32001806)。
Non-alcoholic fatty liver disease (NAFLD) has become a global issue and a severe threat to public health.However, to date, no approved therapeutic drugs have been developed. Dietary interventions with naturalproducts ...
关键词：Non-alcoholic steatohepatitis(NASH) Krüppel-like factor 4 Nuclear translocation CHEMOKINE Lipid metabolism 
Selenocysteine methyltransferase SMT catalyzed the synthesis of Se-methylselenocysteine to regulate the accumulation of glucosinolates and sulforaphane in broccoli
《Horticultural Plant Journal》2024年第5期1151-1164,共14页Qi Wu Junwei Wang Yuxiao Tian Chunyan Zhou Shuxiang Mao Qiuyun Wu Ke Huang 
the Projects of International Cooperation National Key R&D Program of China(Grant No.2022YFE0108300);the National Key Research and Development Program of China(Grant No.2022YFF1003000);the National Natural Science Foundation of China(Grant Nos.32372682,32272747,32072585,32072568).
Selenocysteine methyltransferase(SMT)is a key enzyme involved in the Se metabolism pathway,and it is responsible for the catalysis of Se-methylselenocysteine(SeMSC)compound formation.Previous studies showed that selen...
关键词：Selenocysteine methyltransferase Transgenic broccoli Se-methylselenocysteine Glucosinolate sulforaphane Selenium 
NRF2 signaling cascade in amyotrophic lateral sclerosis:bridging the gap between promise and reality
《Neural Regeneration Research》2024年第5期1006-1012,共7页Pauline Tarot Christelle Lasbleiz Jean-Charles Liévens 
supported by a grant from the Association Française contre les Myopathies(AFM Téléthon;grant 23667,to JCL).
Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor neurons.Symptoms include muscle weakness and atrophy,spasticity,and progressive paralysis.Currently,there is no treatment to r...
关键词：amyotrophic lateral sclerosis C9orf72 NRF2 oxidative defense oxidative stress SULFORAPHANE superoxide dismutase 1 TDP43 
BoMyrosinase plays an essential role in sulforaphane accumulation in response to selenite treatment in broccoli
《Horticultural Plant Journal》2024年第2期488-502,共15页Qiuyun Wu Qi Wu Yuxiao Tian Chunyan Zhou Shuxiang Mao Junwei Wang Ke Huang 
funded by the National Key Research and Development Program of China (Grant Nos.2022YFF1003000,2022YFE0108300);the Natural Science Foundation of China (Grant Nos.32272747,32072585,32072568);the Natural Science Foundation of Hunan Province (Grant Nos.2021JJ30324,2021JJ30345);the Outstanding Youth Project of Educational Department of Hunan Province (Grant No.20B275)。
Sulforaphane, a naturally specialized metabolite, plays significant roles in human disease prevention and plant defense. Myrosinase(MY) is a key gene responsible for the catalysis of sulforaphane formation, but the mo...
关键词：Brassica oleracea var.italica MYROSINASE BoMY SULFORAPHANE Selenite treatment 
Sulforaphane,an NRF2 agonist,alleviates ferroptosis in acute liver failure by regulating HDAC6 activity
《Journal of Integrative Medicine》2023年第5期464-473,共10页Yan-qiong Zhang Chun-xia Shi Dan-mei Zhang Lu-yi Zhang Lu-wen Wang Zuo-jiong Gong 
Objective Acute liver failure(ALF)is characterized by severe liver dysfunction,rapid progression and high mortality and is difficult to treat.Studies have found that sulforaphane(SFN),a nuclear factor E2-related facto...
关键词：Acuteliverfailure SULFORAPHANE NRF2 HDAC6 Ferroptosis 
Sulforaphane prevents LPS‑induced inflammation by regulating the Nrf2‑mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis被引量：2
《Journal of Animal Science and Biotechnology》2023年第5期2093-2106,共14页Dan Shao Wenxiang Shen Yuyang Miao Zhen Gao Menghao Pan Qiang Wei Zuoting Yan Xiaoe Zhao Baohua Ma 
supported by Fuping County Dairy Goat High-efficiency Breeding Technology R&D and Extension Application Project(No.K3380216101);the Dairy Goat High-efficiency Breeding Technology Research and Application Project(No.K4040121023).
Background Mastitis not only deteriorates the composition or quality of milk,but also damages the health and pro-ductivity of dairy goats.Sulforaphane(SFN)is a phytochemical isothiocyanate compound with various pharma...
关键词：AUTOPHAGY Goat mammary epithelial cells INFLAMMATION NRF2 Oxidative stress SULFORAPHANE 
Broccoli products supplemented beers provide a sustainable source of dietary sulforaphane
《Food Bioscience》2023年第1期413-419,共7页Paola Sanchez-Bravo Angel Abellan Pedro JZapata Cristina García-Viguera Raúl Domínguez-Perles María Jose Gimenez 
funded by the grant for the recall of the Spanish university system for the training of young doctors(Margarita Salas,04912/2021)funded by the European Union-Next Generation EU and the Ministry of Universities of Spain.
Broccoli is a highly consumed vegetable due to its content of bioactive nutrients and non-nutrients,including glucosinolates and isothiocyanates.Also,the consumption of craft beer has been boosted by the seek for enha...
关键词：Healthy foods Beverages BRASSICA ISOTHIOCYANATES UHPLC-ESI-MS/MS Sensory properties 
Sulforaphane enhances Nrf2-mediated antioxidant responses of skeletal muscle induced by exhaustive exercise in HIIT mice
《Food Science and Human Wellness》2022年第5期1355-1361,共7页Yangwenjie Wang Yang Xiang Ruiqi Wang Xiangning Li Jianxiong Wang Siwang Yu Ying Zhang 
supported by Winter Sports Nutrition Research Center in Beijing Sport University supported by Herbalife Nutrition~(TM);Scientific Research Program Funded by Shaanxi Provincial Education Department(20JK0993 to Y.X.);Exercise and Physical Fitness,the Key Laboratory of Ministry of Education in Beijing Sport University。
Nuclear factor erythroid-derived 2-like 2(Nrf2)is the master regulator of antioxidant defenses.High-intensity interval training(HIIT)has been proposed as a time-efficient training program and has become a substantial ...
关键词：SULFORAPHANE Nrf2(nuclear factor erythroid-derived 2-like 2) Skeletal muscle ANTIOXIDANT HIIT(high-intensity interval training) MICE 
Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway被引量：3
《Acta Pharmacologica Sinica》2022年第6期1473-1483,共11页Yi-kuan Wu Zheng-nan Ren Sheng-long Zhu Yun-zhou Wu Gang Wang Hao Zhang Wei Chen Zhao He Xian-long Ye Qi-xiao Zhai 
This research was supported by the National Natural Science Foundation of China(Grant No.31871773 to QXZ,81600664 to XLY and 31471321 to ZH).
Most studies regarding the beneficial effect of sulforaphane(SFN)on non-alcoholic fatty liver disease(NAFLD)have focused on nuclear factor E2-related factor 2(Nrf2).But the molecular mechanisms underlying the benefici...
关键词：non-alcoholic fatty liver disease SULFORAPHANE fibroblast growth factor 21 fibroblast growth factor receptor-1 P38MAPK insulin sensitivity 
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