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CHEMOKINE: 作品数：252被引量：1356H指数：19; 导出分析报告; 相关作者：王健崔英健孙琳杨慧何甜更多>>; 相关机构：中国医科大学天津医科大学安徽理工大学复旦大学上海医学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划国家教育部博士点基金更多>>

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury: 《Neural Regeneration Research》2025年第8期2231-2244,共14页Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi; supported by the National Natural Science Foundation of China(Key Program),No.11932013;the National Natural Science Foundation of China(General Program),No.82272255;Armed Police Force High-Level Science and Technology Personnel Project;The Armed Police Force Focuses on Supporting Scientific and Technological Innovation Teams;Key Project of Tianjin Science and Technology Plan,No.20JCZDJC00570(all to XC)。; Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand...; 关键词：apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

CCL2-CCR2 axis in cardiovascular disease:research advances and challenges: 《Science Bulletin》2025年第6期820-824,共5页Yang Yang Jiayan Li Jiayou Tang Bo Wang Jing Wang Xuezeng Xu Wangrui Lei Ying Cheng Liwen Liu; supported by the National Natural Science Foundation of China(82270526,82070422,82200330,82071932,82371974,and 82272009);Key Medical Research Projects in Xi’an City(24YXYJ0010);Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Project(TZKN-CXRC-06);Research Plan Project of Shaanxi Institute of Basic Science(22JHQ053);Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project(2022-QCYZH-036).; C-C motif chemokine ligand 2(CCL2)is a member of the chemokine family and is also known as monocyte chemoattractant protein-1.It is a crucial factor for regulating the migration and infiltration of various immune cell...; 关键词：monocyte chemoattractant protein chemokine family cardiovascular disease CCL immune cells migration infiltration c chemokine ligand MONOCYTES

Capsaicin(CAP)exerts a protective effect against ethanol-induced oxidative gastric mucosal injury by modulating the chemokine receptor 4(CCR4)/Src/p47phox signaling pathway both in vitro and in vivo: 《Chinese Journal of Natural Medicines》2025年第2期191-202,共12页Zhiru Yang Haolin Guo Pengfei Zhang Kairui Liu Junli Ba Xue Bai Shiti Shama Bo Zhang Xiaoning Gao Jun Kang; supported by the High-level Talent Research Start-up Project Funding of Henan Academy of Sciences (No.252028037)。; Ethanol(EtOH)is a common trigger for gastric mucosal diseases,and mitigating oxidative stress is essential for attenuating gastric mucosal damage.Capsaicin(CAP)has been identified as a potential agent to counteract ox...; 关键词：CAPSAICIN Gastric mucosal damage Chemokine signaling NF-κB p65

CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第1期92-106,共15页Ru HE Hongyi JIANG Chengchi ZHANG Yuan CHEN Wenshun LIU Xinyue DENG Xiaozheng ZHU Yunye LIU Chuanming ZHENG Yining ZHANG Chengying SHAO Yanting DUAN Jiajie XU; supported by the Scientific Research Fund of the National Health Commission-Zhejiang Provincial Health Major Science and Technology Plan Project(No.WKJ-ZJ-2415);the Key Research and Development Program of Zhejiang Province(No.2024C03166);the Traditional Chinese Medicine Science and Technology Project of Zhejiang Province(No.2022ZB020);the Zhejiang Provincial Natural Science Foundation of China(No.LY21H160049).; Numerous studies have demonstrated that the high expression of CXC motif chemokine ligand 16(CXCL16)in cancer correlates with poor prognosis,as well as tumor cell proliferation,migration,and invasion.While CXCL16 can ...; 关键词：Antioxidant pathway CXC motif chemokine ligand 16(CXCL16) Glutathione peroxidase 1(GPX1) Head and neck squamous cell carcinoma(HNSCC)

The prognostic and immunological impacts of DCX expression:a pan-cancer analysis: 《Cancer Advances》2024年第14期1-8,共8页Xin Li Wan-Rong Li Hao Jin; Tianjin Health Technology Project(Grant no.2022QN106).; Background:Doublecortin(DCX),a microtubule-associated protein,is best known for its critical role in neuronal migration during neural development,where it stabilizes microtubules and guides neurons to their proper pos...; 关键词：pan-cancer analysis tumor microenvironment prognostic biomarker immune infiltration chemokine signaling cancer genomics

Emerging pharmaceutical therapies for targeting cholangiocarcinoma microenvironment and chemokine pathways: 《BIOCELL》2024年第12期1683-1702,共20页ARMAND N.YAZDANI MICHAELA PLETSCH ABRAHAM CHORBAJIAN DAVID ZITSER VIKRANT RAI; Mixed cholangiocarcinoma is a rare and aggressive neoplastic proliferation of biliary tract epithelial cells,accounting for up to 20%of primary liver cancers.It is the second most common primary liver malignancy with ...; 关键词：CHOLANGIOCARCINOMA Chemokine pathways Tumor microenvironment Therapeutic targets

CXCL10 Induces Lytic Reactivation of EBV through EXTL1: 《Advances in Bioscience and Biotechnology》2024年第10期621-635,共15页Bei-Ning Ding Yi-Lin Wu You-Yu Zhang Yong-Guo Li; Epstein-Barr virus (EBV) infects over 90% of the global population, establishing latent infections in most individuals. Under specific conditions like inflammation and immune suppression, EBV can be reactivated, leadi...; 关键词：Epstein-Barr Virus REACTIVATION Inflammation Chemokine (C-X-C Motif) Ligand 10 EXTL1

Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization: 《Food Science and Human Wellness》2024年第5期2727-2740,共14页Xianghui Huang Jia Xu Ye Xu Bingxin Huangfu Feng Zhang Yanzhou Hu Ruxin Gao Xinxin Ren Boyang Zhang Kunlun Huang Xiaoyun He; supported by the Science and Technology project of Henan Province(202102310142);the National Natural Science Foundation of China(32001806)。; Non-alcoholic fatty liver disease (NAFLD) has become a global issue and a severe threat to public health.However, to date, no approved therapeutic drugs have been developed. Dietary interventions with naturalproducts ...; 关键词：Non-alcoholic steatohepatitis(NASH) Krüppel-like factor 4 Nuclear translocation CHEMOKINE Lipid metabolism

Mental disorders after myocardial infarction:potential mediator role for chemokines in heart-brain interaction?: 《Journal of Geriatric Cardiology》2024年第9期913-926,共14页Parth Patel Feiyan Yang Dumitru A.Iacobas Lei Xi; Acute myocardial infarction(MI)remains one of the leading causes of mortality and morbidity in the global communities.A prevailing topic that has attracted increasing attentions over the past few decades is the so-cal...; 关键词：CHEMOKINE DISORDERS POTENTIAL

Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption: 《Acta Pharmaceutica Sinica B》2024年第9期4118-4133,共16页Mengyi Yan Xiayun Chen Xiaotong Li Qianqian Liu Baixue Yu Yi Cen Wei Zhang Yibin Liu Xinxuan Li Ying Chen Tao Wang Shiying Li; the financial support of National Key R&D Program of China(No.2021YFD1800600);the National Natural Science Foundation of China(No.32371394);the Guangdong Basic and Applied Basic Research Foundation(No.2021B1515020043,China);the Special Projects in Key Areas of Colleges and Universities in Guangdong Province(No.2022ZDZX2046,China);Open Research Foundation of State Key Laboratory of Respiratory Diseases(No.SKLRD-OP-202204,China).; The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional treatments.In this work,a transferrin receptor(TfR)targeted immunostimulant(PTI)is fabricated for phot...; 关键词：Transferrin receptor β-Catenin signal pathway Tumor targeting Photodynamic therapy IMMUNOTHERAPY Immunogenic cell death Programmed death ligand 1 C-C motif chemokine ligand 4

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