Capsaicin(CAP)exerts a protective effect against ethanol-induced oxidative gastric mucosal injury by modulating the chemokine receptor 4(CCR4)/Src/p47phox signaling pathway both in vitro and in vivo  

作　　者：Zhiru Yang Haolin Guo Pengfei Zhang Kairui Liu Junli Ba Xue Bai Shiti Shama Bo Zhang Xiaoning Gao Jun Kang 

机构地区：[1]School of Life Sciences,Tianjin University,Tianjin 300072,China [2]School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102499,China [3]Tianjin Pharmaceutical and Cosmetic Evaluation and Inspection Center,Tianjin 300191,China [4]Institute for TCM-X,MOE Key Laboratory of Bioinformatics,Bioinformatics Division,BNRist,Department of Automation,Tsinghua University,Beijing 100084,China [5]Institute of Biomedical Research,Henan Academy of Sciences,Zhengzhou 450046,China

出　　处：《Chinese Journal of Natural Medicines》2025年第2期191-202,共12页中国天然药物(英文版)

基　　金：supported by the High-level Talent Research Start-up Project Funding of Henan Academy of Sciences (No.252028037)。

摘　　要：Ethanol(EtOH)is a common trigger for gastric mucosal diseases,and mitigating oxidative stress is essential for attenuating gastric mucosal damage.Capsaicin(CAP)has been identified as a potential agent to counteract oxidative damage in the gastric mucosa;however,its precise mechanism remains unclear.This study demonstrates that CAP alleviates EtOH-induced gastric mucosal injuries through two primary pathways:by suppressing the chemokine receptor 4(CCR4)/Src/p47phox axis,thereby reducing oxidative stress,and by inhibiting the phosphorylation and nuclear translocation of nuclear factor-κB p65(NF-κB)p65,resulting in diminished inflammatory responses.These findings elucidate the mechanistic pathways of CAP and provide a theoretical foundation for its potential therapeutic application in the treatment of gastric mucosal injuries.

关 键 词：CAPSAICIN Gastric mucosal damage Chemokine signaling NF-κB p65 

分 类 号：R285[医药卫生—中药学]