Mental disorders after myocardial infarction:potential mediator role for chemokines in heart-brain interaction?  

作　　者：Parth Patel Feiyan Yang Dumitru A.Iacobas Lei Xi 

机构地区：[1]Department of Biology,College of Humanities and Sciences,Virginia Commonwealth University,Richmond,VA,USA [2]Department of Cardiology,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [3]The Texas Undergraduate Medical Academy,Prairie View A&M University,Prairie View,TX,USA [4]Pauley Heart Center,Division of Cardiology,Department of Internal Medicine,School of Medicine,Virginia Commonwealth University,Richmond,VA,USA

出　　处：《Journal of Geriatric Cardiology》2024年第9期913-926,共14页老年心脏病学杂志（英文版）

摘　　要：Acute myocardial infarction(MI)remains one of the leading causes of mortality and morbidity in the global communities.A prevailing topic that has attracted increasing attentions over the past few decades is the so-called heart-brain interaction,in particular following a major traumatic event such as MI.Increased prevalence of depression and other mental disorders has been recognized in cardiac patients after MI,coronary catheterization,or cardiothoracic surgeries.In this review,we focus on the potential pathogenic mechanisms and pre-clinical transcriptomic evidence for identifying potential mediators of post-MI depression.We first summarize the conventional mechanistic understanding that leads to the current clinical management of post-MI depression with the use of selective serotonin reuptake inhibitors(SSRIs)and cognitive behavior and exercise therapies.We further envisage a possible role played by certain chemokines,e.g.,Chemokine(C-X-C motif)ligand 12(CXCL12)and Chemokine(C-C motif)ligand 2(CCL22),in serving as signaling molecules to connect the MI-induced heart damage to the pro-depressive changes in brain during the post-MI period.Future in-depth investigations into this chemokine hypothesis will be instrumental in developing new chemokine-targeted therapies for better management of the cardiac patients suffering from post-MI depression.

关 键 词：CHEMOKINE DISORDERS POTENTIAL 

分 类 号：R542.22[医药卫生—心血管疾病]