LETHALITY

作品数：56被引量：110H指数：6
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相关领域：医药卫生更多>>
相关作者：张毅向太和朱启升杨前进汪秀峰更多>>
相关机构：安徽省农业科学院浙江大学中国科学院上海生命科学研究院第二军医大学更多>>
相关期刊：《Journal of Ocean University of China》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Pharmacology & Pharmacy》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划安徽省自然科学基金中国博士后科学基金更多>>
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Factors Associated with Children’s Death Due to Congenital Heart Disease in Two National Hospitals of Niamey
《International Journal of Clinical Medicine》2024年第11期502-511,共10页M’baye Salissou Seck M’baye Samaila Aboubacar Kamaye Moumouni Abdou Siddo Hadjara Garba Moumouni Adehossi Irene Abdoul Djafar Mamoudou Tsague Kengni Hermann Nestor Amadou Douada Issoufou Alzouma Maliki Abdoulaye Moctar Mianroh Hybi Langtar Laouan Hamidou Ngo Yon Laurence Carole Guindo Aissata Ndobo Valerine Siddikatou Djibrilla Touré Ali 
Introduction: Congenital heart disease is a major cause of children’s death. In Niger, despite the frequency of these pathologies, very few studies have been carried out on associated mortality in a paediatric enviro...
关键词：Congenital Heart Disease Associated Factors to Lethality NIGER 
Retro Placental Hematoma: Maternal and Fetal Prognosis at the Maternity of the University Hospital of Bouake
《Open Journal of Obstetrics and Gynecology》2024年第1期44-56,共13页Samake Yaya Djanhan Lydie Estelle Menin-Messou Benie Michele Kouadio Kouadio Narcisse Akanji Iburaima Alamun M’bro Clausen Georgie Boko Dagoun Dagbesse Elysee Camara Sokhona N’guessan Kouadio Ismael Foua Bi Paul Hyacinthe Keita Ismael Vaho Magnificat Marina Kone Minzata Yasmine Doumbia Yacouba 
Introduction: Retroplacental haematoma (RPH) is a very serious complication of pregnancy, with life-threatening consequences for both the mother and foetus. The aim of this study is to determine the incidence and epid...
关键词：Retroplacental Haematoma LETHALITY Bouaké and Prognosis 
A peptide chain release factor 2a gene regulates maize kernel development by modulating mitochondrial function
《The Crop Journal》2023年第6期1731-1741,共11页Hui Zhang Yijian Feng Kunyang Song Guofang Li Jiao Jin Jingjing Gao Yongtian Qin Hongqiu Wang Jinpeng Cheng Zonghua Liu Jihua Tang Zhiyuan Fu 
the National Natural Science Foundation of China(31971893,U2004144);the Key Technologies R&D Program of Henan Province(232102111080,212102110043);Academician Expert Workstation(202305AF150082).
Mitochondrial protein translation that is essential for aerobic energy production includes four essential steps of the mitochondrial ribosome cycle,namely,initiation,elongation,termination of the polypeptide,and ribos...
关键词：Embryo lethality MITOCHONDRION Peptide release factor 2 Zea mays 
Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo
《Acta Pharmaceutica Sinica B》2023年第10期4172-4184,共13页Xiaosen Ouyang Willayat Y.Wani Gloria A.Benavides Matthew J.Redmann Hai Vo Thomas van Groen Victor M.Darley-Usmar Jianhua Zhang 
partially supported by NIHR01-NS064090,R56AG060959,R01AG072895-01,I01 BX-003792,I01 BX004251(to Jianhua Zhang);UAB Neuroscience Core Facilities(NS47466,NS57098);UAB Blue Sky program;UAB Nathan Shock Center P30 AG050886。
The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality control.Cathepsin D(CTSD),is one such lysosomal protease,which when d...
关键词：Cathepsin D transgenic mouse Mitochondrial bioenergetics Apoptosis Cathepsin D knockout mice DOPAMINE Autophagy LYSOSOME Life expectancy Behavior 
Acute Bilirubin Encephalopathy: A Propos of 151 Cases Collected during a Multicentric Study in Senegal
《Open Journal of Pediatrics》2023年第1期50-62,共13页Serigne Tawa Ndiaye Yaye Joor K. B. Dieng Papa Moctar Faye Mohameth Mbodj Sofietou Dieye Khadim Bop Papa Souley Sow Amadou Sow Ndeye Fatou Sow Ibrahima Diop Aziz Faye Sadio Konate Ibrahima Diagne Mousatapha Ndiaye Ousmane Ndiaye 
Introduction: Bilirubin encephalopathy is a debilitating complication of severe neonatal unconjugated bilirubin jaundice. The aim of this study was to determine the frequency of occurrence of this complication and to ...
关键词：ICTERUS ENCEPHALOPATHY PHOTOTHERAPY LETHALITY 
Phytochemical Screening and Toxicity Assessment of Imperata cylindrica (L.) P. Beauv. (Poaceae) Raw Extracts with Brine Shrimp (Artemia salina) Lethality Assay
《Journal of Biosciences and Medicines》2022年第8期153-171,共19页Anne Marie Léticia Konan Koffi Julien Golly Adou Koffi Mathieu Kra Amissa Augustin Adima Essis Esmel Claude Lohoues 
Background: Herbal medicinal preparations are used as dietary supplements for disease prevention and as alternative/complementary medicine. The growing interest in herbal medicine raises the question of its safety and...
关键词：Imperata cylindrica POACEAE Phytochemical Analyses CYTOTOXICITY Artemia salina 
Synergetic lethal energy depletion initiated by cancer cell membrane camouflaged nano-inhibitor for cancer therapy被引量：1
《Nano Research》2022年第4期3422-3433,共12页Fudan Dong Qikun Jiang Lingxiao Li Tian Liu Shiyi Zuo Lin Gao Mengna Fang Yanlin Gao Bingjun Sun Cong Luo Zhonggui He Jin Sun 
This work was financially supported by National Natural Science Foundation of China(No.81773656);Liaoning Revitalization Talents Program(No.XLYC1808017);Shenyang Youth Science and Technology Innovation Talents Program(No.RC190454);National Postdoctoral Foundation of China(No.2021M693868).
Mitochondrial bioenergy plays a vital role in the occurrence and development of cancer.Although strategies to impede mitochondrial energy supply have been rapidly developed,the anticancer efficacy is still far from sa...
关键词：synergetic lethality energy depletion mitochondria-targeting mitochondrial oxidative phosphorylation GLYCOLYSIS 
The COVID-19 Pandemic in Senegal: Experience of an Internal Medicine Department as an Epidemic Treatment Center
《Open Journal of Internal Medicine》2022年第1期13-21,共9页Atoumane Faye Awa Cheikh Ndao Nafissatou Diagne Mouhamed Dieng Maimouna Sow Baidy Sy Kane Boundia Djiba Abdoulaye Pouye 
Introduction: The COVID-19 pandemic has turned the global health system upside down. Senegal recorded its first case on 2 March 2020. As part of its control strategy, the internal medicine department was set up as an ...
关键词：PANDEMIC COVID-19 COMORBIDITIES LETHALITY 
Progression of Frequency and Lethality of Severe Malaria from 2017 to 2020 in the Pediatric Unit of CHUD-Parakou (Benin)
《Open Journal of Pediatrics》2021年第4期551-558,共8页Honorat Francis Lalya Alphonse Noudamadjo Falilatou Agbeille-Mohamed Mèdétinmè Gérard Kpanidja Zinsou Rodrigue Ahodègnon Julien Didier Adédémy Joseph Agossou 
Background: The latest WHO report shows a decline in the performances achieved concerning the f...
关键词：Severe Malaria CHILDREN FREQUENCY LETHALITY BENIN 
Using bio-orthogonally catalyzed lethality strategy to generate mitochondria-targeting anti-tumor metallodrugs in vitro and in vivo被引量：1
《National Science Review》2021年第9期45-54,共10页Xuling Xue Chenggen Qian Qin Tao Yuanxin Dai Mengdi Lv Jingwen Dong Zhi Su Yong Qian Jing Zhao Hong-Ke Liu Zijian Guo 
supported by the National Natural Science Foundation of China(21420102002,21771109,21731004,21807060,22077066 and 22025701);the China Postdoctoral Science Foundation(2019M651874)。
Synthetic lethality was proposed nearly a century ago by geneticists and recently applied to develop precision anti-cancer therapies.To exploit the synthetic lethality concept in the design of chemical anti-cancer age...
关键词：metallodrug cancer therapy mitochondrial targeting bio-orthogonally catalyzed lethality bio-orthogonal reaction 
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