DECITABINE

作品数：42被引量：73H指数：5
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相关领域：医药卫生更多>>
相关作者：王琳许小平曹蕾张浩朱尔佳更多>>
相关机构：台湾神隆股份有限公司复旦大学广东药学院连云港杰瑞药业有限公司更多>>
相关期刊：《Cellular & Molecular Immunology》《当代医学》《药学进展》《Oncology and Translational Medicine》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Biological Evaluation of a Novel 2’-Fluoro Derivative 5-Azacytidine as a Potent DNA Methyltransferase Inhibitor
《Pharmacology & Pharmacy》2024年第11期388-402,共15页Elena Kalinichenko Tatyana Bozhok Roman Zilberman Alesya Panibrat 
Background: DNA methyltransferases (DNMTs) are key epigenetic regulatory enzymes involved in the expression of many genes and are considered as an attractive target for cancer treatment, especially hematological malig...
关键词：Drug Discovery DECITABINE 2’-Fluorodeoxy-Arabino Analog DNA Methyltransferase Enzyme Inhibition Cell Cycle Apoptosis 
Next-generation sequencing reveals relapse and leukemia-free survival risks in newly diagnosed acute myeloid leukemia treated with CAG regimen combined with decitabine
《Cancer Pathogenesis and Therapy》2024年第2期112-120,共9页Sai Huang Peng Chen Lu Wang Lingmin Xu Nan Wang Fei Li Liping Dou Daihong Liu 
supported by the National Natural Science Foundation of China(Nos.82200169,82270162,82270224,and 82070178);the National Key R&D Program of China(No.2021YFA1100904);the Beijing Natural Science Foundation of China(No.7222175);the Military Medical Support Innovation and Generate Special Program(No.21WQ034);the Special Research Fund for Health Protection(No.21BJZ30).
Background:Acute myeloid leukemia(AML)is a heterogeneous hematopoietic malignancy whose prognosis is associated with several biomarkers.Decitabine,a deoxyribonucleic acid(DNA)methyltransferase(DNMT)in-hibitor,combined...
关键词：Acute myeloid leukemia Next-generation sequencing Prognosis DNA methyltransferase CHEMOTHERAPY 
Author correction to‘Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics’[Acta Pharm Sin B 12(2022)4458–4471]
《Acta Pharmaceutica Sinica B》2024年第5期2359-2360,共2页Qiang Niu Yu Liu Yujing Zheng Ziwei Tang Yuna Qian Ruogu Qi Jianliang Shen Ping Zhao 
The authors regret that there is an error in Fig.6 in the article due to the mistake of copying and pasting in the process of assemblingfigures and negligence in the proofreading.Although it does not affect the conclus...
关键词：journal CORRECTION conclusion 
Decitabine in combination with idarubicin within a modified busulfan/cyclophosphamide conditioning regimen for patients with advanced myelodysplastic syndrome:A prospective multicenter clinical cohort study
《Chinese Medical Journal》2024年第9期1115-1117,共3页Yigeng Cao Mingyang Wang Fuxu Wang Wenwen Guo Yueshen Ma Xiaoyun Li Yi He Aiming Pang Rongli Zhang Weihua Zhai Xin Chen Qiaoling Ma Jialin Wei Donglin Yang Yong Huang Dan Feng Jia Liu Xin Gao Shupeng Wen Wen Wang Tao Wang Ying Li Xiaosheng Fang Yingchun Li Xiaohan Zhang Yun Cai Yongqi Wang Weijie Cao Runqing Lu Sizhou Feng Rong Guo Yuewen Fu Xin Du Zhuogang Liu Xin Wang Ling Wang Liangming Ma Chuanfang Liu Xuejun Zhang Mingzhe Han Erlie Jiang 
supported by grants from the Tianjin Health Science and Technology Project(No.TJWJ2022MS001);Clinical research project of Tianjin Society of Hematology and Regenerative Medicine(No.2022 TSHRM08004);Key Project of Tianjin Natural Science Foundation(No.20JCZDJC00410);CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-073);Haihe Laboratory of Cell Ecosystem Innovation Fund(No.22HHXBSS00034);National Natural Science Foundation of China(Nos.82070192,8230012348,and 82170217)
To the Editor:Allogeneic hemopoietic stem cell transplantation(allo-HSCT)represents the only long-term survival treatment choice for patients with myelodysplastic syndromes(MDS)and MDS/myeloproliferative neoplasm(MPN)...
关键词：REGIMEN myelo PATIENTS 
Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer:a clinical and translational study
《Frontiers of Medicine》2024年第2期357-374,共18页Haoyu Wang Zhengyuan Wang Zheng Wang Xiaoyang Li Yuntong Li Ni Yan Lili Wu Ying Liang Jiale Wu Huaxin Song Qing Qu Jiahui Huang Chunkang Chang Kunwei Shen Xiaosong Chen Min Lu 
supported by the National Natural Science Foundation of China(No.82130075 to Min Lu,No.82073292 to Min Lu,No.81772797 to Xiaosong Chen,No.82072937 to Xiaosong Chen,No.82072897 to Kunwei Shen,No.82002773 to Zheng Wang,No.81900157 to Ying Liang);SJTU Transmed Awards Research(to Min Lu),Shanghai Municipal Education Commission-Gaofeng Clinical Medicine(No.828318 to Min Lu and No.20172007 to Xiaosong Chen);Shanghai Excellent Youth Academic Leader(No.20XD1422700 to Min Lu);Program of Shanghai Science and Technology Committee(No.21S11900100 to Min Lu);Dawn Program of Shanghai Education Commission(No.21SG18 to Min Lu);Samuel Waxman Cancer Research Foundation(to Min Lu);Foundation of National Facility for Translational Medicine(Shanghai)(No.NRCTM(SH)-2021-08).
p53 is mutated in half of cancer cases.However,no p53-targeting drugs have been approved.Here,we reposition decitabine for triple-negative breast cancer(TNBC),a subtype with frequent p53 mutations and extremely poor p...
关键词：p53 mutation triple-negative breast cancer DECITABINE DNMT1 IRF7 innate immune response 
Efficacy of Yisui granule(益髓颗粒)on myelodysplastic syndromes in SKM-1 mouse xenograft model through suppressing Wnt/β-catenin signaling pathway
《Journal of Traditional Chinese Medicine》2024年第1期78-87,共10页WU Jieya HOU Li ZHANG Xiaoyuan Elizabeth Gullen GAO Chong WANG Jing 
Clinical Translational Research of Beijing Municipal Science and Technology Commission,Administrative Commission of Zhongguancun Science Park-funded Project:Study on Mechanisms and Efficacy of Yisui granule Treating Low and Intermediate Risk of Myelodysplastic Syndromes via DNA Demethylation(No.Z211100002921018);National Natural Science Foundation of Chinafunded Projects:Study on Molecular Mechanisms of Yisui granule Treating Myelodysplastic Syndromes via Regulating DNA Methylation(No.81503575);Mechanism Study of Tea Polyphenols activating c GAS-STING Pathway to Inhibit Lung Adenocarcinoma Immune Escape based on Redox Balance(No.82172760);the Golden Bridge Project of Beijing Association for Science and Technology-funded Project:Study on Mechanisms of Yisui granule Treating Low and Intermediate Risk of Myelodysplastic Syndromes via DNA Demethylation(No.ZZ20059)。
OBJECTIVE:To unmask the underlying mechanisms of Yisui granule(益髓颗粒,YSG)for the treatment of Myelodysplastic syndromes(MDS).METHODS:Our study used an SKM-1 mouse xenograft model of MDS to explore the anti-tumor po...
关键词：myelodysplastic syndromes Wnt signaling pathway beta catenin DECITABINE SURVIVAL adverse effects sFRP5 gene methylation Yisui granule 
Chidamide,Decitabine,Cytarabine,Aclarubicin,and Granulocyte Colony-stimulating Factor Therapy for Patients with Relapsed/Refractory Acute Myeloid Leukemia:A Retrospective Study from a Single-Center
《Current Medical Science》2023年第6期1151-1161,共11页Fan-cong KONG Ling QI Yu-lan ZHOU Min YU Wen-feng HUANG Fei LI 
the National Natural Science Foundation of China(No.81960043 and No.81600180);Natural Science Foundation of Jiangxi Province(No.20192ACB20030 and No.20203BBGL73197);Science and Technology Innovation Base Construction Project of Jiangxi Province(No.20212BCG74001 and No.20211ZDG02006).
Objective Preclinical evidence and clinical trials have suggested synergistic effects of epigenetic modifiers in combination with cytotoxic agents for the treatment of leukemia.However,their efficacy in patients with ...
关键词：relapsed/refractory acute myeloid leukemia histone deacetylase inhibitor DNA methyltransferase inhibitor salvage therapy 
Therapeutic effect of folic acid combined with decitabine on diabetic mice被引量：2
《International Journal of Ophthalmology(English edition)》2023年第11期1766-1772,共7页Gang Du Yong Yan Jun-Feng Gao Chun-Yan Guo Xiao Shen Xun-Wen Lei 
Supported by the Natural Science Foundation of Gansu Province(No.21JR7RA361).
AIM:To evaluate the therapeutic effect of folic acid combined with decitabine on diabetic mice.METHODS:The diabetic model of db/db mice were randomly divided into model group,folic acid group,decitabine group,folic ac...
关键词：diabetic model folic acid DECITABINE APOPTOSIS MOUSE 
Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer
《Acta Pharmaceutica Sinica B》2023年第10期4305-4317,共13页Tong Gao Xiao Sang Xinyan Huang Panpan Gu Jie Liu Yongjun Liu Na Zhang 
supported by National Natural Science Foundation of China(Nos.82173757,82173756)。
Chemoimmunotherapy has been approved as standard treatment for triple-negative breast cancer(TNBC),but the clinical outcomes remain unsatisfied.Abnormal epigenetic regulation is associated with acquired drug resistanc...
关键词：Triple negative breast cancer CHEMOIMMUNOTHERAPY EPIGENETICS DEMETHYLATION DECITABINE Immunogenic cell death Anti-tumor immunity Combination therapy 
T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine:A case report
《World Journal of Clinical Cases》2023年第26期6200-6205,共6页Sungwoo Park Eun Jeong Jeong Jung Hun Kang Gyeong-Won Lee Se-Il Go Dong-Hyun Lee Eun-Ha Koh 
BACKGROUND Mixed-phenotype acute leukemia(MPAL)is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid antigens.However,consensus regarding the ideal management strategy for ...
关键词：Mixed-phenotype acute leukemia Venetoclax DECITABINE Case report 
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