KALLIKREIN

作品数：51被引量：99H指数：6
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相关领域：医药卫生更多>>
相关作者：胡成进陈英剑孙晓明彭英吕瑞妍更多>>
相关机构：济南军区总医院中山大学附属第二医院山东大学北京协和医学院更多>>
相关期刊：《神经损伤与功能重建》《World Journal of Stem Cells》《Translational Neurodegeneration》《Chinese Journal of Structural Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry国家高技术研究发展计划更多>>
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Keratin 1 modulates intestinal barrier and immune response via kallikrein kinin system in ulcerative colitis
《World Journal of Gastroenterology》2025年第6期62-75,共14页Xiang-Qian Dong Ying-Hui Zhang Juan Luo Mao-Juan Li Lan-Qing Ma Ya-Ting Qi Ying-Lei Miao 
Supported by the National Natural Science Foundation of China,No.82160113;the“Xingdian Talents”Support Project of Yunnan Province,No.RLMY20220007;the Yunnan Province Clinical Research Center for Digestive Diseases,No.202102AA100062;the Applied Basic Research Projects of Yunnan Province,No.2019FE001-039.
BACKGROUND External factors in ulcerative colitis(UC)exacerbate colonic epithelial permea-bility and inflammatory responses.Keratin 1(KRT1)is crucial in regulating these alterations,but its specific role in the progre...
关键词：Keratin 1 Ulcerative colitis Kallikrein kinin system Digestive system diseases Bradykinin High molecular weight kininogen Intestinal barrier function Inflammatory cytokines 
Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple‐negative breast cancer
《Cancer Innovation》2023年第5期376-390,共15页Yue Song Guiying Bai Xiaoqing Li Liyan Zhou Yiran Si Xiaohui Liu Yilin Deng Yehui Shi 
National Natural Science Foundation of China,Grant/Award Number:82002816。
Background:Metaplastic breast carcinoma(MBC)is a rare breast cancer subtype;most cases are triple‐negative breast cancers(TNBCs)and are poorly responsive to conventional systemic therapy.Few potential diagnostic and ...
关键词：bioinformatics analysis differentially expressed genes EMT KLK5 metaplastic breast carcinoma 
Human Kallikrein-2 and Free Prostate Specific Antigen as Biomarkers for Early Detection of Prostate Cancer, Sudan: A Case-Control Study
《Open Journal of Clinical Diagnostics》2023年第1期9-21,共13页Osman Khalid Yousif Badreldin Elsonni Abdalla Mohammed Alimam M. Ahmed Sami Mahjoub Taha Ahmed Al Siddiq Ebraheem Muawia Mohamed Ahmed Elhadi Abdalla Ahmed 
Background: Prostate cancer (PCa) is considered one of the major health threats facing males in Sudan. Prostate-specific antigen (PSA) test is the most important laboratory test used in the diagnosis of prostate cance...
关键词：Kallikrein-2 PSA FPSA Prostate Cancer SUDAN 
Association of Haplotypes in Exon 4 of KLK2 Gene with Raised Serum Prostate-Specific Antigen
《American Journal of Molecular Biology》2023年第1期57-66,共10页Innocent S. I. Ogbu Ogochukwu A. Nwankwo Chinemere C. Ogbu Emmanuel Nna Kingsley K. Anya Malachy O. Odoh David C. Obasi 
The standard diagnostic modalities for Prostate Cancer (PC) include serum Prostate-Specific Antigen (PSA) assay, Digital Rectal Examination (DRE), and histological examination of prostate biopsy. They are limited by l...
关键词：Prostate Cancer Prostate-Specific Antigen Kallikrein 2 Gene Genetic Mutations Haplotypes Short Nucleotidepolymorphism 
Jiepx METTL3介导KLK6的m6A修饰促进胃癌细胞的细胞活力被引量：2
《解剖学研究》2020年第6期515-519,共5页赵飞 李爱丽 冯运章 张学强 张伟 刘小慧 霍浩然 
河北省卫健委科技计划项目(20150454)
目的探讨甲基转移酶样3(METTL3)是否介导Kallikrein相关肽酶6(KLK6)的N6-甲基腺苷(m6A)修饰促进胃癌细胞的细胞活力。方法通过m6A抗体纯化胃癌细胞MGC⁃803和正常胃细胞GES⁃1中的m6A修饰的mRNA,通过实时荧光定量PCR检测这些mRNA中KLK6的...
关键词：胃癌细胞株 MGC-803 甲基转移酶样3 Kallikrein相关肽酶6 N6-甲基腺苷 细胞活力 
Exogenous pancreatic kininogenase protects against renal fibrosis in rat model of unilateral ureteral obstruction被引量：10
《Acta Pharmacologica Sinica》2020年第12期1597-1608,共12页Li-zhe Jin Hui-ying Li Jian Jin Shang-guo Piao Xiong-hu Shen Yan-ling Wu Jia-chong Xu Long-ye Zhang Yu-ji Jiang Hai-lan Zheng Ying-shun Jin Sheng Cui Kang Luo Yi Quan Can Li 
This work was supported by the National Natural Science Foundation of China(no.81560125,no.81760293;no.81760132,and no.81760668)and the Korean Health Technology Research and Development Project,Ministry for Health and Welfare(grants HI14C3417 and HI16C1641).
Tissue kallikrein has protective function against various types of injury.In this study,we investigated whether exogenous pancreatic kininogenase(PK)conferred renoprotection in a rat model of unilateral ureteral obstr...
关键词：KALLIKREIN renal fibrosis oxidative stress APOPTOSIS AUTOPHAGY 
Meta-analysis of the clinical efficacy and safety of Urinary Kallidinogenase in the treatment of acute cerebral infarction被引量：1
《TMR Clinical Research》2020年第4期131-141,共11页Yuan Qin Qian Yi Hui-Hui Shi Ya-Lin Qi Jing-Yue Hu 
Objective:To evaluate the clinical efficacy and safety of Urinary Kallidinogenase for Injection in the treatment of acute cerebral infarction.Methods:PubMed,The Cochrane Library,Embase,CNKI,VIP,Wan Fang and bibliograp...
关键词：Human urinary kallikrein Urinary Kallidinogenase Acute cerebral infarction Randomized controlled trial META-ANALYSIS 
Neuroprotective mechanism of TMP269, a selective class ⅡA histone deacetylase inhibitor, after cerebral ischemia/reperfusion injury被引量：5
《Neural Regeneration Research》2020年第2期277-284,共8页Lu Su Dan Liang Shen-Yi Kuang Qiang Dong Xiang Han Zheng Wang 
supported by the National Natural Science Foundation of China,No.81501134(to ZW)
TMP269 is a selective class ⅡA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of ...
关键词：blood-brain barrier drug treatment ENDOTHELIAL cell permeability HISTONE DEACETYLASE inhibitor NEUROPROTECTION stroke tissue KALLIKREIN TMP269 
NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition被引量：1
《Frontiers of Medicine》2019年第6期646-657,共12页Jiajia Hu Wenbin Shen Qian Qu Xiaochun Fei Ying Miao Xinyun Huang Jiajun Liu Yingli Wu Biao Li 
NES1 gene is thought to be a tumor-suppressor gene.Our previous study found that overexpression of NES1 gene in PC3 cell line could slow down the tumor proliferation rate,associated with a mild decrease in BCL-2 expre...
关键词：androgen-independent prostate cancer normal epithelial cell-specific 1/kallikrein 10 sodium/iodide symporter radiation therapy proliferation 
Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia被引量：6
《Asian Journal of Andrology》2019年第5期508-515,共8页Kai Cui Yang Luan Zhe Tang Chuan-Chang Li Tao Wang Shao-Gang Wang Zhong Chen Ji-Hong Liu 
The aim of this study was to investigate the mechanism by which a diet inducing high hyperhomocysteinemia(HHcy)leads to the deterioration of erectile function in rats and whether this is inhibited by expression of the...
关键词：ENDOTHELIAL cell erectile function FIBROSIS human tissue kallikrein-1 HYPERHOMOCYSTEINEMIA OXIDATIVE stress 
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