A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors  

作　　者：Jianquan Guo Dongsheng Tan Chenmei Lou Shiying Guo Xing Jin Haijing Qu Lijia Jing Sijin Li 

机构地区：[1]Key Laboratory of Saline-alkali Vegetation Ecology Restoration,Ministry of Education,College of Life Science,Northeast Forestry University,Harbin,150040,China [2]Department of Nuclear Medicine,First Hospital of Shanxi Medical University,Taiyuan,030001,Shanxi,China

出　　处：《Bioactive Materials》2022年第3期554-565,共12页生物活性材料（英文）

基　　金：This work was financially supported by National Natural Science Foundation of China(No.81701822);Heilongjiang Province Science Foundation for Youths(No.QC2018090);the Fundamental Research Funds for Central Universities(No.2572017PZ09);China Postdoctoral Science Foundation(No.2016M600238);Heilongjiang Postdoctoral Special Fund(No.LBH-TZ1601);Northeast Forestry University Double First-Rate Construction Fund(No.000/41113281).

摘　　要：Nanoparticle-based chemophotothermal therapy(CPT)is a promising treatment for multidrug resistant tumors.In this study,a drug nanococktail of DIR825@histone was developed by employing doxorubicin(DOX),NIR dye IR825 and human histones for interventional nucleus-targeted CPT of multidrug resistant tumors with an interventional laser.After localized intervention,DIR825@histone penetrated tumor tissues by transcytosis,efficiently entered tumor cells and targeted the cell nuclei.DIR825@histone also exhibited good photothermal performance and thermal-triggered drug release.Efficient multidrug resistant tumor inhibition was achieved by enhanced CPT sensitization and MDR reversion via nuclear targeting.Moreover,an interventional laser assisted DIR825@histone in inhibiting multidrug resistant tumors by promoting the sufficient delivery of laser energy inside the tumor while reducing skin injury.Therefore,DIR825@histone together with this interventional nucleus-targeted CPT strategy holds great promise for treating multidrug resistant tumors.

关 键 词：Human histones Chemotherapy Photothermal therapy Nuclear targeting Localized intervention Drug resistant tumor 

分 类 号：R73[医药卫生—肿瘤]