Histones of Neutrophil Extracellular Traps Induce CD11b Expression in Brain Pericytes Via Dectin-1 after Traumatic Brain Injury  

作　　者：Yang-Wuyue Liu Jingyu Zhang Wanda Bi Mi Zhou Jiabo Li Tiantian Xiong Nan Yang Li Zhao Xing Chen Yuanguo Zhou Wenhui He Teng Yang Hao Wang Lunshan Xu Shuang-Shuang Dai 

机构地区：[1]Department of Biochemistry and Molecular Biology,School of Basic Medicine,Army Medical University,Chongqing,400038,China [2]Department of Neurosurgery,Daping Hospital,Army Medical University,Chongqing,400042,China [3]Molecular Biology Center,State Key Laboratory of Trauma,Burn,and Combined Injury,Daping Hospital,Army Medical University,Chongqing,400042,China [4]Department of Pathophysiology,College of High Altitude Medicine,Army Medical University,Chongqing,400038,China [5]Brigade 1 of Medical Undergraduates,School of Basic Medicine,Army Medical University,Battalion 1,Chongqing,400038,China

出　　处：《Neuroscience Bulletin》2022年第10期1199-1214,共16页神经科学通报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(32000670 and 82071779);Chongqing Research Program of Basic Research and Frontier Technology(cstc2017jcyjAX0338).

摘　　要：The brain pericyte is a unique and indispensable part of the blood-brain barrier(BBB),and contributes to several pathological processes in traumatic brain injury(TBI).However,the cellular and molecular mechanisms by which pericytes are regulated in the damaged brain are largely unknown.Here,we show that the formation of neutrophil extracellular traps(NETs)induces the appearance of CD11b^(+)pericytes after TBI.These CD11b^(+)pericyte subsets are characterized by increased permeability and pro-inflammatory profiles compared to CD11b-pericytes.Moreover,histones from NETs by Dectin-1 facilitate CD11b induction in brain pericytes in PKC-c-Jun dependent manner,resulting in neuroinflammation and BBB dysfunction after TBI.These data indicate that neutrophil-NET-pericyte and histone-Dectin-1-CD11b are possible mechanisms for the activation and dysfunction of pericytes.Targeting NETs formation and Dectin-1 are promising means of treating TBI.

关 键 词：PERICYTE NEUTROPHIL TBI NET DECTIN-1 

分 类 号：R285.5[医药卫生—中药学]