p73基因及其在妇科肿瘤中的研究进展  

p73 gene and its role in gynecological tumors:an advance

作　　者：彭平平[1] 黄利鸣[1] 王艳林[1] 

机构地区：[1]三峡大学医学院分子生物学研究所,宜昌443002

出　　处：《第二军医大学学报》2011年第3期334-336,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(30873282);湖北省自然科学基金(2009CDA060)~~

摘　　要：p73作为p53家族成员之一,因具有与p53极为类似的结构和功能受到广泛关注。其中p73基因全长模式TAp73能够引起细胞周期停滞和诱导细胞凋亡,并能作用于p53的靶基因,推测TAp73很可能是另一个新型的抑癌基因。该基因的深入研究将为癌症的诊断和治疗提供新视野。本文将对p73的结构、生物学功能及其与妇科肿瘤发生、发展、预后之间的关系简要阐述。As a member of p53 family,p73 is gaining increasing attention because it has high structural and functional homology with p53.TAp73,a full-length isoform of p73,can arrest cell cycle and induce cell apoptosis;it may also exert its effect on the target gene of p53,and is therefore considered as a new tumor suppressor gene.Further research on p73 may cast new lights on the diagnosis and therapy of cancer.This paper describes the structure and function of p73 and its relationship with development,progression and prognosis of gynecological tumors.

关 键 词：P73 肿瘤抑制基因 细胞凋亡 女性生殖器肿瘤 乳腺肿瘤 

分 类 号：R737.3[医药卫生—肿瘤] R737.9[医药卫生—临床医学]