虫草素的研究开发现状与思考  

Cordycepin research and exploitation:progress and problems

作　　者：杨涛[1,2] 董彩虹[1] 

机构地区：[1]中国科学院微生物研究所真菌地衣系统学重点实验室,北京100101 [2]中国科学院研究生院生命科学学院,北京100049

出　　处：《菌物学报》2011年第2期180-190,共11页Mycosystema

摘　　要：虫草素是第一个从真菌中分离出来的核苷类抗菌素,具有抑菌、抗肿瘤、抗炎等非常广谱的生物学活性,目前已经成为一个研究热点。对虫草素的菌株来源、生物合成、提取纯化、分子生物学研究现状等方面进行了总结,对有关专利进行了评价和分析,提出从种质资源入手拓宽虫草素来源,优化虫草素的提取纯化方法,深入研究其生物合成途径,并呼吁重视真菌研究中所用材料的科学名称。Cordycepin,the first nucleoside antibiotic isolated from Fungi,has been a hotspot nowadays due to a variety of bio-activities,such as antimicrobial,anti-tumor,anti-inflammatory activities and so on.The previous studies on cordycepin,including the fungal sources,extraction,purification and molecular biology,were summarized in the present paper.The patents on cordycepin both at home and abroad have also been analyzed and evaluated.It was suggested that broadening the fungal strain sources,optimizing the method of extraction and purification as well as deepening the research on biosynthesis pathway are useful to overcome the bottleneck in cordycepin production.In addition,the importance of the scientific names used in the study of mycology was emphasized.

关 键 词：虫草素 蛹虫草 纯化 产率 开发 

分 类 号：S567.35[农业科学—中草药栽培]