尖顶羊肚菌菌丝体水提液对实验型胃溃疡的作用  

Effect of Morchella conica mycelial water extract on experimental gastric ulcer

作　　者：高明燕[1,2] 郑林用[3] 余梦瑶[2] 魏巍[2] 罗霞[2] 王世宽[1] 

机构地区：[1]四川理工学院生物工程学院,自贡643000 [2]四川省中医药科学院中药细胞与分子生物学实验室,成都610041 [3]四川省农业科学院,成都610066

出　　处：《菌物学报》2011年第2期325-330,共6页Mycosystema

基　　金：国家农业产业技术体系四川食用菌创新团队精深加工研究岗位建设项目(川农业[2009]75号);国家农业产业技术体系药用菌栽培岗位

摘　　要：研究尖顶羊肚菌菌丝体水提液对4种实验型胃溃疡模型的治疗作用。以大鼠幽门结扎致胃溃疡为模型,测定各组胃粘膜损伤指数、胃液分泌量和胃酸浓度;以大鼠乙酸烧灼、小鼠乙醇致胃粘膜损伤和小鼠水浸应激胃溃疡为模型,分别测定溃疡面积。结果表明尖顶羊肚菌菌丝体水提液可以不同程度抑制胃酸的分泌,减少胃液量,减少溃疡面积,促进溃疡面积的愈合,因此尖顶羊肚菌菌丝体水提液具有抗实验型胃溃疡的作用。To investigate the effects of water extract from Morchella conica mycelium on four kinds of experimental gastric ulcer models,four kinds of model animals with experimental gastric ulcer were established.The gastric ulcer index,gastric juice volume and acidity were measured in pyloric ligation models.The gastric ulcer index was measured in acetic acid-buming,alcohol and water-immersion-restraint stress of gastric ulcer models.The results show that different doses of Morchella mycelium water extract inhibit gastric acid secretion,reduce gastric juice acidity and promote healing of ulcer.Therefore,Morchella mycelium water extract possesses the inhibitory and protective effect on experimental gastric ulcer.

关 键 词：尖顶羊肚菌 幽门结扎 乙酸灼烧 乙醇 水浸应激 抗胃溃疡 

分 类 号：R285.5[医药卫生—中药学]