复发-缓解型多发性硬化的磁共振波谱表现  

MR Spectroscopy Findings of Relapsing-Remitting Multiple Sclerosis

作　　者：颜立群[1] 侯亚平[2] 耿左军[1] 宋振虎[1] 宋鹏[1] 郜晓彬[1] 刘怀军[1] 

机构地区：[1]河北医科大学第二医院医学影像科,河北石家庄050000 [2]河北省血液中心

出　　处：《实用放射学杂志》2011年第3期315-318,共4页Journal of Practical Radiology

基　　金：河北省卫生厅重点科技研究计划（20090388）.

摘　　要：目的 探讨复发-缓解型多发性硬化（relapsing-remitting muldple sclerosis,RRMS）的磁共振波谱（MRS）表现,提高其诊断水平.方法 收集本院经临床确诊的多发性硬化24例的MRS影像学资料,回顾分析其MRS特点.结果 24例急性期均可见明显的NAA峰及NAA/Cr减低,伴随着NAA峰减低,其中22例有明显的Cho峰增加,16例Lac峰增加,其中4例出现明显的Cr峰减低,6例出现较为明显的Lip峰和mI峰 在急性期过后的数天至数周内,本组病例中5例原减低的NAA有所恢复,其余19例均持续减低达数月,Cho、Cr及Lip峰逐渐恢复至正常水平,mI峰持续增加达数月.结论 RRMS的MRS表现具有一定的特点,它对早期发现多发性硬化具有一定的意义,与传统MRI相结合可以提高RRMS的诊断率.Objective To analyze MRS characteristics of relapsing-remitting multiple sclerosis（RRMS）. Methods 24 cases with RRMS confirmed clinically were collected. The imaging features were retrospectively analysed. Results In the acute stage,all 24 cases showed apparent decrease in NAA and NAA/Cr,accompanied by decreases in NAA, there were increase in Cho and Lac in 22 eases and 16 cases,respectively,4 cases showed decrease in Cr,6 cases had ml and Lip,and NAA/Cr in all cases showed decrease. After the acute phase over a period of days to weeks,there was a progressive return to normal levels in Lac and intensities of Cr also return. The Cho and Lip typically return to normal over months. But ml lasts for several months. Conclusion MRS appearances of RRMS are of some characteristic,which are of certain significance in early detecting the multiple sclerosis, and if it combined with conventional MRI,the diagnostic accuracy of MRS will be improved.

关 键 词：脑 多发性硬化 磁共振波谱 N-乙酰天门冬氨酸 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]