宫颈癌（Ⅰb2～Ⅲb期）动脉内化疗栓塞的临床疗效分析  

Analysis of Clinic Therapeutic Effect of Intra-arterial Chemoembolization in Cervical Cancer（Stage.Ⅰb2-Ⅲb）

作　　者：吕益忠 李捷 祝司龙 姜海霞 陈英 陈亚梅 

机构地区：[1].江苏大学附属镇江市第四人民医院放射科,江苏镇江212001

出　　处：《实用放射学杂志》2011年第3期430-433,共4页Journal of Practical Radiology

摘　　要：目的 探讨局部进展期宫颈癌（Ⅰb2 -Ⅲb期）动脉内化疗栓塞（介入治疗）的临床疗效.方法 53例局部进展期宫颈癌行动脉内化疗栓塞,其中35例介入治疗后行子宫全切除及盆腔淋巴结清扫术.评估介入治疗的临床疗效,并对手术切除的标本进行组织病理学观察,记录是否存在盆腔淋巴转移、手术切缘阳性、脉管腔隙侵犯、卵巢转移,与未行介入治疗对照组进行比较.结果 介入治疗临床总有效率75.5% 介入治疗后肿瘤细胞可出现不同程度变性、坏死,盆腔淋巴结转移（P=0.016）、手术切缘阳性（P=0.026）、脉管间隙侵犯（P=0.003）较对照组明显减少 Ⅲ期宫颈癌可手术切除率37.5%.结论 宫颈癌动脉内化疗栓塞可有效降低肿瘤病理学风险,使部分Ⅲ期宫颈癌患者获得手术切除机会,疗效显著.Objective To investigate the clinical therapeutic effect of intra-artery chemoembolization in local advanced cervical cancer（ Ⅰb2-Ⅲb）. Methods Intra-arterial chemoembolization was administered in 53 cases with local advanced cervical cancer patients. Radical hysterectomy and pelvic lymphadenectomy in 35 patients were permitted after interventional therapy . Clinical therapeutic effect and pathologic findings were evaluated. The pelvic lymph node metastasis, positive in the resection margins, vascular space involvement and ovarian metastasis were recorded in the patients undergone surgery and compared with control group. Results The clinical overall response rate was 75.5%. The tumor＇s cells would be variety degenerative and necrotic after interventional therapy. The incidence of pelvic lymph node metastasis,positive resection margins, vascular space involvement were significantly lower than that in the control group（P=0. 016 ; P=0. 026 and P=0. 003 ）. The resectable rate in stage Ⅲ cervical cancer achieved was 37.5 %. Conclusion Intra-artery chemoembolizition is able to eliminate effectively the pathologic risk factors,and improved the resectable rate in patients with stage cervical cancer.

关 键 词：宫颈癌 化疗 疗效 介入放射学 

分 类 号：R737.33[医药卫生—肿瘤] R815[医药卫生—临床医学]