c-erb-B2和TopoⅡα在乳腺癌组织中表达及其临床意义  

Expression and clinical significance of c-erb-B2 and TopoⅡα in breast cancer

作　　者：王凤良[1] 谢晖[1] 殷虹[1] 汤永峰[2] 李凤山[2] 陆澄[1] 

机构地区：[1]南京医科大学附属南京市妇幼保健院乳腺外科,210004 [2]南京医科大学附属南京市妇幼保健院病理科,210004

出　　处：《江苏医药》2011年第5期541-543,共3页Jiangsu Medical Journal

摘　　要：目的探讨c-erb-B2、拓扑异构酶Ⅱα(TopoⅡα)在乳腺癌组织中的表达及临床意义。方法采用免疫组化法检测110例乳腺癌石蜡切片标本中c-erb-B2和TopoⅡα的表达。结果 110例乳腺癌组织中,c-erb-B2阳性表达率为21.8%,TopoⅡα阳性表达率为56.4%。c-erb-B2表达与淋巴结转移状态、临床分期相关(P<0.01);TopoⅡα与肿瘤细胞雌激素受体(ER)状态相关(P<0.05)。TopoⅡα与c-erb-B2表达呈正相关(P<0.01)。结论 c-erb-B2、TopoⅡα在乳腺癌组织中的高表达与乳腺癌的发生发展密切相关,联合检测c-erb-B2、TopoⅡα对于乳腺癌的化疗具有指导意义,也是判断预后的重要指标。Objective To investigate the expression and significance of c-erb-B2 and DNA topoisomeraseⅡα（TopoⅡα） in breast cancer.Methods c-erb-B2 and TopoⅡα expressions were detected in 110 cases of breast cancer tissues by immunohistochemistry.Results The expression of c-erb-B2 was positively correlated with lymph nodes metastasis and clinical stage（P0.01）.The expression of TopoⅡα was positively correlated with estrogen receptor（ER） status（P0.05）.The expression of TopoⅡα was significantly correlated with the expression of c-erb-B2（P0.01）.Conclusion Overexpressions of c-erb-B2 and TopoⅡα are related with progression of breast cancer.Combined detection of c-erb-B2 and TopoⅡα expressions may play an important role in guiding chemotherapy and predicting prognosis.

关 键 词：乳腺癌 C-ERB-B2 拓扑异构酶Ⅱα 

分 类 号：R737[医药卫生—肿瘤]