色素上皮细胞衍生因子在膀胱癌组织中的表达与手术后复发的相关性  

Correlation of pigment epithelium-derived factor mRNA expression and recurrence of bladder cancer

作　　者：蒋华[1] 陈建红[1] 王卫东[1] 杭霞[1] 张荣良[1] 姜昊文[2] 丁强[2] 

机构地区：[1]丹阳市人民医院泌尿外科,212300 [2]复旦大学附属华山医院

出　　处：《江苏医药》2011年第5期547-548,共2页Jiangsu Medical Journal

摘　　要：目的探讨膀胱移行细胞癌(膀胱癌)中色素细胞衍生因子(PEDF)mRNA在膀胱癌组织中的表达与手术后复发相关性。方法对50例患者进行术后5年的随访,并根据膀胱癌组织中PEDF mRNA的表达情况进行相关分析。结果 40例患者得到术后5年的随访。15例术后复发;PEDF在膀胱癌组织中表达下调与肿瘤的恶性程度和微血管密度相关;且PEDF表达下调与膀胱癌手术后复发呈显著正相关。结论 PEDF可能通过调节细胞因子而发挥其抗肿瘤血管生长、转移和复发。膀胱癌组织中PEDF表达可作为预测膀胱癌术后复发的一个独立因素。Objective To investigate the correlation of pigment epithelium-derived factor（PEDF） mRNA expression and recurrence of bladder cancer.Methods Fifety patients underwent surgery for bladder cancer were followed-up for 5 years and the expression of PEDF mRNA was detected.Results Fourty patients received 5 years of follow-up.Tumor recurred in 15 patients.Down-regulation of PEDF expression was closely associated with the malignancy and microvascular density and positively correlated to the recurrence of bladder cancer.Conclusion The expression of PEDF may play a role in anti-tumor growth and metastasis by regulating the cell factors.PEDF can be an independent factor to predict the recurrence of bladder cancer.

关 键 词：色素上皮细胞衍生因子 膀胱移行细胞癌 

分 类 号：R737[医药卫生—肿瘤]