TSLC1和MPP3在胰腺癌中的表达及其意义  

Clinical significance of the expression of TSLC1 and MPP3 in pancreatic cancer

作　　者：刘志清[1,2] 刘修莉[1,2] 龚发良[1,2] 任习芳[1,2] 陈畅[1,2] 李玲[1,2] 潘志红[1,2] 袁玲莉[1,2] 陈蓉[1,2] 

机构地区：[1]宜昌市第一人民医院 [2]三峡大学人民医院消化内科,湖北省宜昌市443000

出　　处：《世界华人消化杂志》2011年第4期379-383,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨TSLC1和MPP3两种蛋白在胰腺癌中的表达和临床病理意义.方法:采用免疫组织化学S-P法检测37例胰腺癌组织、12例胰腺炎组织和10例正常胰腺组织中TSLC1和MPP3两种蛋白的表达.结果:TSLC1、MPP3蛋白在胰腺癌组织中的阳性表达率均明显低于在正常胰腺组织和胰腺炎组织中的表达(21.62%vs70.00%,75.00%;27.03%vs80.00%,66.67%,P<0.05或0.01).TSLC1和MPP3蛋白的异常表达均与胰腺癌的分化程度、淋巴结转移和TNM分期相关(均P<0.05),而与患者的性别、年龄、部位和病理分型无关.在37例胰腺癌中TSLC1与MPP3蛋白表达呈显著正相关(rs=0.715,P<0.01).结论:胰腺癌中存在TSLC1和MPP3基因的失活和蛋白表达下调,两者可能通过TSLC1-MPP3级联反应共同参与胰腺癌的发生、发展和转移.AIM：To investigate the clinical significance of the expression of TSLC1（tumor suppressor in lung cancer 1） and MPP3（membrane protein,palmitoylated 3） in pancreatic cancer.METHODS：Immunohistochemistry was used to measure the expression of TSLC1 and MPP3 in 10 normal pancreatic tissue specimens,12 pancreatitis specimens,and 37 pancreatic cancer specimens.RESULTS：The positive rates of TSLC1 and MPP3 expression in pancreatic carcinoma were significantly lower than those in normal pancreatic tissue and pancreatitis（21.62% vs 70.00%,75.00%;27.03% vs 80.00%,66.67%,all P 0.05 or 0.01）.The expression of TSLC1 and MPP3 was significantly correlated with tumor differentiation,lymph node metastasis,and TNM stage in pancreatic cancer（all P 0.05）,but not with gender,age,tumor location,and pathological type（all P 0.05）.A significant positive correlation was found between the expression of TSLC1 and MPP3 in pancreatic cancer（P 0.01）.CONCLUSION：Down-regulated expression of TSLC1 and MPP3 may be involved the pathogenesis,progression,and metastasis of pancreatic carcinoma.

关 键 词：胰腺癌 肺癌抑制基因1 膜蛋白 棕榈酰化3 免疫组织化学 

分 类 号：R735.9[医药卫生—肿瘤]