CHD患者血清可溶性CD40L检测的临床意义  

Clinical Significance of Serum Soluble CD40L Level in Coronary Heart Disease

作　　者：杨兆颖[1,2] 李金梁[3] 刘文娟[1] 谷金宁[2] 吴绥生[2] 

机构地区：[1]黑龙江省医院老年心内科,150036 [2]吉林大学第一医院干部病房 [3]黑龙江省医院心内科

出　　处：《放射免疫学杂志》2011年第2期163-165,共3页Journal of Radioimmanology

摘　　要：目的:探讨冠心病(CHD)患者血清可溶性CD40L(sCD40L)水平变化的临床意义。方法:应用酶联免疫吸附法(ELISA)对入选的90例CHD患者[急性心梗(AMI)患者28例,不稳定型心绞痛(UAP)患者35例,稳定型心绞痛(SAP)患者27例]的外周血sCD40L进行检测,并与30例正常对照者血清sCD40L的浓度进行比较。结果:AMI组和UAP组血清sCD40L水平明显高于SAP组和正常对照组(P<0.05),随访期各组心血管事件发生率与各组sCD40L水平的梯度差异一致。结论:sCD40L的升高在CHD的发生发展中起重要作用,是反映斑块不稳定的指标之一,其水平变化对了解病情、观察预后有重要的临床价值。Objective To investigate the clinical significance of the serum level of soluble CD40 ligand（sCD40L） in coronary heart disease（CHD）.Methods Enzyme-linked immunosorbent assay（ELISA） was used to measure sCD40L in 90 patients with coronary heart disease（28 with acute myocardial infarction,35 with unstable angina pectoris and 27 with stable angina pectoris） and 30 matched healthy controls.Results sCD40L level was significantly higher in patients with acute myocardial infarction and unstable angina pectoris than that of stable angina pectoris and controls.Incidence of high risk of cardiovascular events during follow-up period were more in patients with high sCD40L level than that of those with lower sCD40L level.Conclusion The level of sCD40L increase in coronary heart disease,which may be related to the pathogenesis of CHD,can be used as a potential marker of plaque instability,and the change of sCD40L could reflect the disease status as well as progress of disease in patients with coronary heart disease.

关 键 词：冠状动脉粥样硬化性心脏病 血清可溶性CD40L 

分 类 号：R735.2[医药卫生—肿瘤]