Altered proteomic expression in the prefrontal cortex of morphine-addicted rats  

作　　者：Ye Yang Chunyan Zhang Han Liu Bin Wang Haiying Lin Lisha Wu 

机构地区：[1]Department of Biochemistry, Luzhou Medical College, Luzhou 646000, Sichuan Province, China [2]Audio-bisual Educational Center, Luzhou Medical College, Luzhou 646000, Sichuan Province, China [3]Department of Cardiology, the People's Hospitial of Luzhou, Luzhou 646000, Sichuan Province, China [4]Department of Physiology, Luzhou Medical College, Luzhou 646000, Sichuan Province, China

出　　处：《Neural Regeneration Research》2011年第4期300-303,共4页中国神经再生研究（英文版）

基　　金：sponsored by a grant from the Sichuan Provincial Education Department(Influence of AGS3 on"reversible protein phosphorylation"in cortical neu-rons of morphine-addicted rats),No.2005B016

摘　　要：The prefrontal cortex is involved in the regulation and control of substance addiction-related cognitive, behavioral, and emotional changes. The present study identified prefrontal cortex protein profiles in morphine-addicted rats; these were subsequently compared with normal rats. Results showed 87 protein spots with differentially expressed levels in the morphine addiction group, with the majority located in meta acid zones at pH 4.2-6.8 and having a molecular weight of 30-110 kDa In addition, 2 protein spots were identified as being associated with neurotoxicity （Snap25 isoform β-Snap25 of synaptosomal-associated protein 25 and βactin）.The prefrontal cortex is involved in the regulation and control of substance addiction-related cognitive, behavioral, and emotional changes. The present study identified prefrontal cortex protein profiles in morphine-addicted rats; these were subsequently compared with normal rats. Results showed 87 protein spots with differentially expressed levels in the morphine addiction group, with the majority located in meta acid zones at pH 4.2-6.8 and having a molecular weight of 30-110 kDa In addition, 2 protein spots were identified as being associated with neurotoxicity （Snap25 isoform β-Snap25 of synaptosomal-associated protein 25 and βactin）.

关 键 词：ADDICTION MORPHINE prefrontal cortex PROTEOME 2-dimensional gel electrophoresis 

分 类 号：Q426[生物学—神经生物学] S511[生物学—生理学]