miRNA and nasopharyngeal carcinoma  

作　　者：ZHAO LuQing1,2,3,CHEN Xue1,2,3 & CAO Ya1,2,3 1 Key Laboratory of Carcinogenesis and Invasion,Ministry of Education,Changsha 410078,China 2 Key Laboratory of Carcinogenesis,Ministry of Health,Changsha 410078,China 3 Cancer Research Institute,Xiangya School of Medicine,Central South University,Changsha 410078,China 

出　　处：《Chinese Science Bulletin》2011年第8期722-728,共7页

基　　金：supported by the National Key Basic Research Program of China (2011CB504300);the Key Project of National Natural Science Foundation of China (30930101)

摘　　要：MicroRNAs(miRNAs) constitute a family of small non-coding RNA molecules 22-25 nucleotides in length.miRNAs control the expression of target genes at the post-transcriptional level by inhibiting translation or by degrading target mRNA through binding to complementary sequences in the 3'-untranslated regions.Recent studies have demonstrated that miRNAs are intimately involved in processes leading to nasopharyngeal carcinoma,such as the Epstein-Barr virus-encoded latent membrane protein 1 activated signal transduction pathways,gene-regulatory networks,mitosis,tumor angiogenesis,invasion and migration.Exploring the relationship between miRNAs and the development of nasopharyngeal carcinoma,will further the understanding of this cancer and provide new avenues for diagnosis and treatment.MicroRNAs （miRNAs） constitute a family of small non-coding RNA molecules 22-25 nucleotides in length, miRNAs control the expression of target genes at the post-transcriptional level by inhibiting translation or by degrading target mRNA through binding to complementary sequences in the 3＇-untranslated regions. Recent studies have demonstrated that miRNAs are intimately involved in processes leading to nasopharyngeal carcinoma, such as the Epstein-Barr virus-encoded latent membrane protein 1 activated signal transduction pathways, gene-regulatory networks, mitosis, tumor angiogenesis, invasion and migration. Exploring the relationship between miRNAs and the development of nasopharyngeal carcinoma, will further the understanding of this cancer and provide new avenues for diagnosis and treatment.

关 键 词：miRNAs 鼻咽癌 非编码RNA 小分子RNA 信号转导通路 潜伏膜蛋白1 基因调控网络 肿瘤血管生成 

分 类 号：R739.63[医药卫生—肿瘤]