An Efficient Synthesis of 2-Substituted Benzoxazoles via RuCl3.3H2O Catalyzed Tandem Reactions in Ionic Liquid  

作　　者：范学森 何艳 王洋洋 张新迎 王键吉 

机构地区：[1]School of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, China

出　　处：《Chinese Journal of Chemistry》2011年第4期773-777,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20772025, 20972042）, Innovation Scientists and Technicians Troop Construction Projects of Henan Province （No. 104100510019）, and the Natural Science Foundation of Henan Province （No. 092300410237）.

摘　　要：An efficient synthesis of 2-substituted benzoxazoles through RuCl3·3H2O catalyzed, air oxidized tandem reactions of 2-aminophenols and aldehydes in [bmim]BF4 was developed. This synthetic strategy has such advantages as mild reaction conditions, cost-free oxidant, readily available starting materials, and recyclable catalyst and solvent. As an application, it was successfully used in the synthesis of the unreported 5-（benzoxazol-2-yl）-2＇-deoxyuridines with potential biological activities.An efficient synthesis of 2-substituted benzoxazoles through RuCl3·3H2O catalyzed, air oxidized tandem reactions of 2-aminophenols and aldehydes in [bmim]BF4 was developed. This synthetic strategy has such advantages as mild reaction conditions, cost-free oxidant, readily available starting materials, and recyclable catalyst and solvent. As an application, it was successfully used in the synthesis of the unreported 5-（benzoxazol-2-yl）-2＇-deoxyuridines with potential biological activities.

关 键 词：2-Substituted benzoxazoles ruthenium chloride tandem reaction ionic liquids NUCLEOSIDE 

分 类 号：O623.413[理学—有机化学] X703.1[理学—化学]