COX-2、CCR7表达与乳腺癌临床病理参数的关系  

Correlation between the expressions of COX-2,CCR7 and clinicopathologic parameters in breast cancer

作　　者：余术宜[1] 李建哲[2] 吉午阳[2] 周志群[2] 庞琼[2] 陈玉祥[3] 

机构地区：[1]中南大学现代分析测试中心 [2]中南大学药学院 [3]卫生部纳米生物技术重点实验室,湖南长沙410078

出　　处：《中国现代医学杂志》2011年第8期990-992,997,共4页China Journal of Modern Medicine

摘　　要：目的探讨环氧合酶2(cyclooxygenase 2,COX-2)、C-C家族趋化因子受体7(C-C chemokine receptor 7,CCR7)表达与乳腺癌临床病理学参数的关系,并分析COX-2、CCR7表达的相关性。方法用免疫组织化学检测乳腺癌组织80例、乳腺癌癌旁组织15例中COX-2、CCR7的表达,分析其表达与临床病理学参数的关系,对COX-2、CCR7的表达进行相关性分析。结果在乳腺癌组织,COX-2、CCR7均高表达,表达率分别为42.5%和38.8%,两者表达有相关性(P<0.05)。COX-2、CCR7高表达均与肿瘤的病理分化、肿瘤大小、淋巴转移、TNM分期相关(P<0.05),与组织学分型、患者年龄无关。结论 COX-2、CCR7在乳腺癌组织高表达,两者表达有相关性,且与乳腺癌临床病理学参数有关。提示临床上联合检测COX-2和CCR7对乳腺癌转移的预测可能会有所帮助。【Objective】 To assess the co-expression of COX-2 and CCR7 in human breast cancer and analyze their relationship and correlation with clinicopathologic parameters.【Methods】 COX-2 and CCR7 expressions in the tissue samples of primary tumors from 80 breast cancer patients and normal breast tissue samples from 15 breast cancer patients were examined by immunohistochemica assay.Then,their relationships and correlation with clinicopathologic parameters were analyzed.【Results】 COX-2 and CCR7 were over expression in breast cancer tissues,the positive rate of COX-2 and CCR7 in the primary tumor was 42.5% and 38.8%,respectively.A significant correlation was found between the expression scores of COX-2 and CCR7（P 0.05）,and both also were correlated with lymph node metastasis,histology,primary tumor size and TNM stage（P 0.05）,but both were not related to histology type and patients＇ age（P 0.05）.【Conclusions】 The over expression of COX-2 and CCR7 in human breast cancer were correlated,and significantly associated with clinicopathologic parameters.The results indicate that COX-2 and CCR7 might be a co-marker of prediction the metastasis of breast cancer.

关 键 词：乳腺癌 COX-2 CCR7 肿瘤转移 

分 类 号：R737.9[医药卫生—肿瘤]