膀胱上皮癌ΔNp63、p53及ki-67基因表达与预后的相关性研究  

Correlation between expressions of ΔNp63,p53 and ki-67 gene and prognosis of bladder epihelial cancer

作　　者：伍季 吕萍[1,3] 李云祥[1,2] 

机构地区：[1]四川省南充市中心医院 [2]川北医学院第二临床学院泌尿外科,四川南充637000 [3]川北医学院附属医院耳鼻喉科,四川南充637000

出　　处：《现代泌尿外科杂志》2011年第2期152-155,共4页Journal of Modern Urology

摘　　要：目的探讨ΔNp63在膀胱移行细胞癌(transitional cell carcinoma of bladder,TCCB)中作用及联合检测ΔNp63、p53和ki-67与膀胱上皮癌预后的相关性。方法用免疫组化检测56例膀胱移行细胞癌组织ΔNp63、p53和ki-67的表达,分析免疫染色结果与病理分级、分期和预后的关系。结果膀胱移行细胞癌中ΔNp63、p53和ki-67阳性表达率明显高于正常膀胱黏膜,在高级别、浸润性癌组织中的阳性表达率明显高于低级别、浅表性癌组织,各组阳性表达率差异有统计学意义(P<0.05);ΔNp63与p53、Ki-67均呈正相关,rs′分别为0.298、0.316,相关性有统计学意义(P<0.05)。结论ΔNp63可能是TCCB发生和发展的重要促进因素,与膀胱癌的预后密切相关,联合检测ΔNp63、p53和ki-67可以更好地判断TCCB的预后。Objective To investigate the expression and clinical significance of ΔNp63 in（TCCB）,and explore correlation between the expression of ΔNp63,p53 and ki-67,and the prognosis of TCCB.Methods The expressions of ΔNp63,p53,and ki-67 of 56 patients with TCCB were detected with the immunohistochemical staining assay.The relations between the expressions of the three bio-markers,clinical stages,pathological types,and prognosis of TCCB were analyzed.Results The expressions rate of ΔNp63 was significantly higher in TCCB than in the normal epithelium of bladder,and the expression rate of ΔNp63,p53 and ki-67 were significantly higher in the high-grade and invasive TCCB than in low-grade and superficial TCCB.The differences had statistical significant（P0.05）.ΔNp63 was positively correlated with p53 and ΔNp63,with rs′ being 0.298 and 0.316 respecitvely,which was statistically significant（P 0.05）.Conclusions ΔNp63 was highly expressed in TCCB,which was closely associated with the progression of TCCB,but the role of ΔNp63 needs further exploration.Detecting the expression of ΔNp63 as well as p53 and ki-67 can better indicate the prognosis of TCCB.

关 键 词：膀胱癌 ΔNP63 P53 KI-67 免疫组化 

分 类 号：R737.14[医药卫生—肿瘤]