^(18)F-FDG PET-CT在非小细胞肺癌骨转移诊断中的应用  

^(18)F-FDG PET-CT for the Detection of Bone Metastases in Patients with Non-small Cell Lung Cancer

作　　者：王广丽[1] 杨涛 张成琪[1] 宋吉清[3] 邓凯[1] 

机构地区：[1]山东省千佛山医院放射科,250014 [2]莱芜市钢铁集团有限公司医院放射科,山东271126 [3]山东省立医院放射科,250021

出　　处：《临床放射学杂志》2011年第3期350-352,共3页Journal of Clinical Radiology

基　　金：山东省科技厅科技攻关项目(编号:2009GG10002040)

摘　　要：目的探讨非小细胞肺癌(NSCLC)骨转移的的特点及18F-脱氧葡萄糖正电子发射计算机断层摄影术(18F-FDG PET-CT)对NSCLC骨转移的诊断价值。资料与方法回顾性分析114例经病理证实的NSCLC患者的临床资料和18F-FDG PET-CT显像结果,并与CT结果进行对比。结果 NSCLC骨转移率为25.44%(29/114),其中腺癌36.21%(21/58),鳞癌14.89%(7/47),混合癌14.29%(1/7),2例大细胞肺癌患者未发生骨转移;共有骨转移病灶103处,骨转移好发部位为肋骨(34.95%)和胸椎(33.98%),其次是骨盆(13.59%)和腰椎(13.59%)。18 F-FDG PET-CT显像发现101处病灶,均呈放射性摄取增高,对NSCLC骨转移诊断的敏感性为98.06%;CT发现91处病灶,对NSCLC骨转移诊断的敏感性为88.35%;两者差别有统计学意义。结论 NSCLC中腺癌骨转移率最高,骨转移常见部位是肋骨和胸椎。18F-FDG PET-CT能发现CT所不能发现的早期NSCLC骨转移病灶,对NSCLC骨转移的正确诊断很有意义。Objective To evaluate the clinical features of bone metastases of NSCLC and the clinical value of 18F-FDG PET-CT in the diagnosis of bone metastases.Materials and Methods The clinical data and 18F-FDG PET-CT imaging results of 114 cases with NSCLC were retrospectively analyzed.Results Total bone metastases ratio of NSCLC was 25.44%（29/114）.Different ratios of bone metastases occurred in different histological classification of lung cancer：36.21%（21/58） in lung adenocarcinoma,14.89%（7/47） in lung squamous cell carcinoma,14.29%（1/7） in lung mixed tumor,no bone metastases has been found in the 2 case of big cell lung cancer.There were 103 bone metastases.The most common metastatic sites were ribs（34.95%） and thoracic vertebrae（33.98%）,followed with pelvis（13.59%） and lumber vertebrae（13.59%）.The sensibility of 18F-FDG PET-CT and CT for detecting bone metastases were 98.06%（101/103） and 88.35%（91/103） respectively.The sensibility of PET CT was significantly higher than that of CT.Conclu-sion The common sites of bone metastases were ribs and thoracic vertebrae in NSCLC cases,meanwhile lung adenocarcinoma has the highest ratio of bone metastases.18F FDG PET CT which has high significant in the diagnosis of bone metastases,is a very effective imaging modality for early diagnosing bone metastases in patients with NSCLC.

关 键 词：非小细胞肺癌 骨转移瘤 体层摄影术 发射型计算机 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤]