survivin与p53、Ki67在复发转移性乳腺癌组织中表达及相关性研究  

Study on Expressions of Survivin,p53,and Ki67 in Patients with Recurrence or Metastasis Breast Cancer and Their Correlations

作　　者：管小青[1] 吴骥[1] 顾书成 郑向欣[1] 陈焰[1] 吴建强[1] 侍孝红[2] 江小玲[2] 袁牧[1] 吴际生[1] 

机构地区：[1]南京鼓楼医院集团宿迁市人民医院乳腺外科,江苏宿迁223800 [2]南京鼓楼医院集团宿迁市人民医院病理科,江苏宿迁223800

出　　处：《中国普外基础与临床杂志》2011年第3期290-294,共5页Chinese Journal of Bases and Clinics In General Surgery

基　　金：江苏省卫生厅资助课题(项目编号:H200960)~~

摘　　要：目的研究survivin与p53、Ki67在复发转移性乳腺癌组织中的表达情况及相关性。方法我院2005年1月至2010年1月期间将86例乳腺癌胸壁局部复发或腋窝、锁骨上淋巴结转移灶切除并作病理检查,同时进行免疫组织化学检测,分析复发转移性乳腺癌患者原发灶和转移灶组织中survivin与p53、Ki67的表达情况并进行比对。结果 survivin、p53及Ki67在复发转移性乳腺癌组织中的表达阳性率明显高于其在原发性乳腺癌组织中的表达阳性率,分别为survivin:90.70%(78/86)比61.63%(53/86),2χ=20.014 895,P<0.001;p53:68.60%(59/86)比52.33%(45/86),χ2=4.766 968,P<0.05;Ki67:62.79%(54/86)比46.51%(40/86),2χ=4.597 927,P<0.05。在复发转移性乳腺癌组织中p53或Ki67阴性患者中survivin表达阳性率也高于其在原发性乳腺癌组织中的表达阳性率(70.37%比24.39%,2χ=14.071 113,P<0.05;75.00%比39.13%,2χ=6.540 373,P<0.05);survivin在原发性乳腺癌组织和复发转移性乳腺癌组织表达阳性者与p53、Ki67表达阳性者的相关系数分别为0.876 214、0.773 643和0.725 164、0.698 112,P<0.05,均呈正相关。结论在复发转移性乳腺癌组织中survivin与p53、Ki67表达阳性率均较其在原发性乳腺癌组织中的表达增高,提示该类患者预后不良。Objective To explore the expressions of survivin,p53,and Ki67 in recurrence or metastasis breast cancer tissue,and explore their correlations and clinical significance.Methods Eighty-six patients with the chest wall local recurrence,axillary or supraclavicular lymph node metastases get treated in this hospital between January 2005 and January 2010 were excised and the expressions of survivin,p53,and Ki67 were detected by immunohistochemistry test,then compared them between the recurrence and metastasis breast cancer tissues and the primary breast cancer tissues.Results The positive expression rate of survivin,p53,and Ki67 in the recurrence and metastasis breast cancer tissues were significantly higher than those in the primary breast cancer tissues,survivin： 90.70%（78/86） versus 61.63%（53/86）,χ2=20.014 895,P0.001;p53： 68.60%（59/86） versus 52.33%（45/86）,χ2=4.766 968,P0.05;Ki67： 62.79%（54/86） versus 46.51%（40/86）,χ2=4.597 927,P0.05.The positive expression rates of survivin in the recurrence and metastasis patients with p53,Ki67 negative expression were significantly higher than those of the primary breast cancer tissue（70.37% versus 24.39%,χ2=14.071 113,P0.05;75.00% versus 39.13%,χ2=6.540 373,P0.05）.The correlation coefficient of survivin with p53 and Ki67 positive expressions in the recurrence and metastasis breast cancer tissue and the primary breast cancer tissue were 0.876 214,0.773 643 and 0.725 164,0.698 112,respectively,P0.05.Conclusion The positive expression rates of survivin,p53,and Ki67 which increase in recurrence and metastasis breast cancer tissue indicate bad prognosis.

关 键 词：复发转移性乳腺癌 SURVIVIN P53 KI67 

分 类 号：R737.9[医药卫生—肿瘤]