神经元特异性烯醇化酶、S-100蛋白于新生儿黄疸中的研究  

Research on neurons specificity ene alcoholize enzyme,S-100 protein in the neonatal jaundice

作　　者：熊金国[1] 张荣贵[1] 杨永玲[1] 

机构地区：[1]广州医学院附属深圳沙井医院儿科,518104

出　　处：《齐齐哈尔医学院学报》2011年第3期354-355,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨神经元特异性烯醇化酶、S-100蛋白在新生儿黄疸早期的表达及其意义。方法选取35例2008年6月~2010年3月期间在我科正常分娩的足月新生儿黄疸患儿为观察组,32例同一时期在我科正常分娩的足月新生儿为对照组,分别测定并比较两组新生儿血清NSE和S-100蛋白含量及胆红素水平。结果观察组血清NSE、S-100蛋白含量及B/A值分别为（97.45±39.36）ng/ml、（0.38±0.16）μg/L、（0.64±0.17）,对照组分别为（45.23±14.87）ng/ml、（0.27±0.09）μg/L、（0.30±0.08）,观察组结果显著高于对照组,差异有统计学意义（P〈0.05）。结论测定血清中NSE与S-100蛋白含量及了解B/A值,可预测新生儿黄疸早期脑损伤的发生。Objective To study the neurons specificity ene alcoholize enzyme, S -100 protein in the neonatal jaundice early expression and its significance. Methods 35 patients were selected from June 2008 to 2010 during march in our department of normal childbirth term newborns jaundice patients for the observation group, 32 cases the same period in my branch of normal childbirth term newborns as control group, were measured and compared between the two groups neonatal serum NSE and S-100 protein content and bilirubin level. Results The observation group serum NSE,S-100 protein content and B/A alues for （97.45±39.36）ng/mL, （0.38±0.16）μg/L, 0.64±0.17,respectively control group （ 45.23±14.87）ng/mL, （0.27±0.09）μg/L, 0.30±0.08, the observation group results significantly higher than control group, difference was statistically significant（P0.05）. Conclusions To determine serum NSE and S-100 protein content and understand B/A value can predict the occurrence of neonatal jaundice early brain damage.

关 键 词：NSE S-100蛋白 B/A 新生儿黄疸 

分 类 号：R743.33[医药卫生—神经病学与精神病学]