乳果糖联合培菲康对肝硬化自发性细菌性腹膜炎肠黏膜屏障功能的影响  

Clinical effect of lactulose and bifid lriple viable on intestinal barrier function in cirrhosis patients with spontaneous bacterial peritonitis

作　　者：储建坤[1] 茹秀丽[2] 张征[3] 霍晓辉[1] 马金城[1] 

机构地区：[1]河北医科大学第一医院消化内科,河北石家庄050031 [2]河北医科大学第一医院妇产科,河北石家庄050031 [3]河北医科大学第一医院检验科,河北石家庄050031

出　　处：《临床荟萃》2011年第9期745-747,共3页Clinical Focus

摘　　要：目的探讨乳果糖联合双歧杆菌/嗜酸性乳杆菌/粪链球菌(培菲康)对肝硬化自发性细菌性腹膜炎患者肠黏膜屏障功能的影响。方法选择肝硬化自发性细菌性腹膜炎患者60例,随机分为常规治疗组(n=30)和联合治疗组(n=30),同时选择健康体检者30例为健康对照组。所有研究对象口服糖分子探针乳果糖、甘露醇,采用高压液相色谱示差法测定尿乳果糖/甘露醇排泄率。结果治疗前常规治疗组和联合治疗组患者尿乳果糖/甘露醇排泄率均显著高于健康对照组,0.127±0.021、0.128±0.019 vs 0.018±0.002(P<0.01)。治疗后联合治疗组尿乳果糖/甘露醇排泄率较常规治疗组明显下降,0.076±0.016 vs 0.085±0.010(P<0.01)。结论乳果糖联合培菲康可以改善肝硬化自发性细菌性腹膜炎患者肠黏膜的通透性,具有临床应用价值。Objective To evaluate the effects of lactulose and bifid lriple viable on intestinal barrier function in hepatitis cirrhotic patients with spontaneous bacterial peritonitis（SBP）.Methods Sixty SBP patients of hepatitis cirrhosis were randomized into two groups：conventional treatment group（n=30） and combined treatment group（n=30）.Health persons from body check were selected as healthy control group（n=30）.All cases were observed for 7 days.To evaluate intestinal permeability,the concentrations of lactulose（LAC） and mannitol（MAN） in urine were measured using high-pressure liquid chromatograph with refractive index detector（HPLC-RID）,and the levels of urinary excretion of LAC/MAN ratios were calculated.Results The levels of urinary excretion of LAC/MAN ratios were significantly higher in conventional treatment group and combined treatment group than that of healthy control group,0.127±0.021,0.128±0.019 vs 0.018±0.002（P0.01）.After treatment for one week,the levels of urinary excretion of LAC/MAN ratios were significantly decreased in combined treating group than conventional treatment group,0.076±0.016 vs 0.085±0.010（P0.01）.Conclusion The intestinal barrier function in hepatitis cirrhosis patients is abnormal.Lactulose and bifid lriple viable are beneficial to intestinal barrier function in hepatitis cirrhotic patients with SBP,and have clinical application value.

关 键 词：肝硬化 腹膜炎 乳果糖 双歧杆菌 肠黏膜屏障 

分 类 号：R575.2[医药卫生—消化系统]