Cyr61基因的生物学功能及在肿瘤发生发展过程中的作用  

The Biological Function and Carcinogenesis of Cyr61 Gene

作　　者：乔英[1] 郭瑞芳 吕有勇[3] 

机构地区：[1]内蒙古医学院 [2]内蒙古自治区人民医院消化内科,内蒙古呼和浩特010017 [3]北京大学临床肿瘤学院北京市肿瘤防治研究所,北京100142

出　　处：《内蒙古医学杂志》2011年第2期182-185,共4页Inner Mongolia Medical Journal

基　　金：内蒙古自治区自然科学基金项目资助(项目编号20080404Zd26)

摘　　要：Cyr61(cysteine-rich 61)是CCN家族第一个被克隆出来的、由生长因子诱导产生的富含半胱氨酸的即刻早期基因产物。作为一种重要的细胞基质调节因子,Cyr61在胚胎发育、伤口修复、血管性疾病及肿瘤的发生发展过程中均发挥重要的生物学作用。研究发现Cyr61在肿瘤组织中广泛表达,并且与肿瘤新生血管形成及肿瘤细胞的增殖与凋亡、转移密切相关。Cyr61在不同细胞中的表达受多种信号通路的调控,可与多种整联蛋白结合激活不同的下游通路,可能通过参与Wnt、NF-kB、Tyrosine Kinase(酪氨酸激酶)、Akt等信号转导通路调控其它癌基因、抑癌基因或凋亡调控因子的表达。Cyr61（cysteine-rich 61）,is the first cloned member of the CCN family,produced by growth factor-induction immediate early gene.Acting as an important extracellular,matrix-associated factor,Cyr61 plays an important biological effects in embryonic development,wound repair,the vascular disease and tumorigenesis.The study found that Cyr61 widely express in tumor tissue,and closely related of tumor angiogenesis,and tumor cell proliferation and apoptosis.The expression of Cyr61 in the cell is affected by many kinds of signaling pathways. Cyr61 can activate different downstream pathways by binding to variety of integrins,may through participating in Wnt,NF-kB Tyrosine Kinase and Akt etc signalling pathways regulate other cancer gene,tumor-suppressor genes or apoptosis regulatory factors of expression.

关 键 词：CYR61 肿瘤 信号通路 

分 类 号：R734.2[医药卫生—肿瘤]