DCF方案治疗进展期胃癌的临床观察  

Clinical observation of DCF for advanced gastric cancer patients

作　　者：韩光锋[1] 汪志求[1] 

机构地区：[1]安庆市立医院肿瘤内科,安徽安庆246001

出　　处：《皖南医学院学报》2011年第2期123-125,共3页Journal of Wannan Medical College

摘　　要：目的：观察多西他赛联合顺铂、5-氟尿嘧啶治疗进展期胃癌的近期疗效和反应。方法：回顾性分析进展期胃癌33例,多西他赛75 mg/m2,静脉滴注,d1;顺铂20 mg/m2静脉滴注,d1~d5;5-Fu 500 mg/m224 h持续泵入,d1~d5。21d为一个周期,2个周期后评价疗效。结果：全组33例患者CR 1例,PR 16例,有效率（CR＋PR）51.5%（17/33）,中位进展时间为4.6个月,中位生存时间为8.1个月。主要不良反应为白细胞下降。结论：DCF方案治疗进展期胃癌疗效较好,且毒副反应可以耐受。Objective：To observe the efficacy and toxicity of combined docetaxel,5-fluorouracil and cisplatin in treatment of patients with advanced gastric cancer.Methods：Thirty-three patients with advanced gastric cancer received intravenous drip of docetaxel at a dose of 75 mg/m2 on d1,cisplatin at a dose of 20 mg/m2 from d1 to d5,5-fluorouracil at a dose of 500 mg/m2 by continuous 24 h ivgtt from d1 to d5,respectively.The treatment was repeated every 3 weeks,with evaluation of the efficacy and adverse effects after two cycles.Results：Of the 33 patients,1 totally responded to the therapy,16 partially responded to the medication,which was effective in 51.5%（17/33）.The median time to progression was 4.5 months,and the median overall survival was 9.9 months.Leucopenia was the major side effects.Conclusion：The combined regimen of DCF is effective and can be tolerated by patients with advanced gastric cancer.

关 键 词：多西他赛 氟尿嘧啶 进展期胃癌 

分 类 号：R735.2[医药卫生—肿瘤]