肝细胞癌的超声造影定量参数与肿瘤内新生动脉的相关性研究  

Contrast-enhanced ultrasonography of hepatoceilular carcinoma： correlation between quantitative parameters and arteries in neoangiogenesis

作　　者：裴小青[1] 刘隆忠[1] 左菲菲[1] 郑玮[1] 李毓红[1] 韩峰[1] 李安华[1] 

机构地区：[1]中山大学附属肿瘤医院暨华南肿瘤学国家重点实验室超声科,广州510060

出　　处：《中华超声影像学杂志》2011年第3期222-225,共4页Chinese Journal of Ultrasonography

摘　　要：目的探讨肝细胞癌（hepatocellular carcinoma, HCC）的超声造影（contrast enhanced ultrasonography,CEUS）定量参数与HCC内新生动脉的关系。方法对115例HCC的CEUS图像进行脱机分析和免疫组化染色，获得感兴趣区的灌注曲线及CEUS定量参数：峰值强度（maximum of intensity, IMAX）、上升时间（rise time, RT）、达峰时间（time to peak, TTP）、平均渡越时间（mean trasit time corresponding to the center of gravity, mTT）、上升斜率（riseslope，RS）和始消时间（washout time，wT）。获得82例HCC内的非成对动脉数，将CEUS定量参数和非成对动脉数进行统计学分析。结果HCC中非成对动脉数与RT、TTP、RS呈中度相关，r分别为-0．446，-0．432，0．431（P〈0．05），与IMAX和wT呈弱相关，r分别为0．303和0．285（P〈0．05）。结论HCC内的新生动脉是HCC动脉相增强的病理生理基础，CEUS定量参数反映了肿瘤灌注情况，与HCC中的非成对动脉数有关。Objective To explore the relationships between the quantitative parameters for contrast- enhanced uhrasonography（CEUS） in hepatocellular carcinoma （HCC） and arteries in neoangiogenesis. Methods One hundred and fifteen HCCs in CEUS were analyzed off-line with dynamic vascular curve of ImageArena and immunohistochemical stained in the tissue slices. Parameters including maximum of intensity（IMAX）, rise time（RT）, time to peak（TTP）, mean trasit time corresponding to the center of gravity（mTT）, rise slope（RS） and washout time（WT） were analyzed by statistics. Unpaired arteries（UAs） of 82 HCC cases were succesfully stained. Results The number of UAs had moderate correlation with RT （r = -0.446）,TTP （r = -0.432） and RS （r =0.431）（P 〈0.05）,and it had mild correlation with IMAX （ r = 0. 303） ,WT （ r = 0. 285）（ P %0.05）. Conclusions Neoangiogenesis is a functional adaptation to altered vascular dynamics. Quantitative parameters of CEUS, reflecting hemodynamics of tumors, are correlated with UAs.

关 键 词：超声检查 微气泡 癌 肝细胞 新生血管化 病理性 

分 类 号：R735.7[医药卫生—肿瘤]