miRNA-21与肿瘤相关研究新进展  

Recent Advances in the Research on the Relationship between miRNA-21 and Cancer

作　　者：杨旸(综述)[1] 康春生(审校)[1] 

机构地区：[1]天津医科大学总医院神经外科,天津市神经病学研究所神经肿瘤实验室,天津市300052

出　　处：《中国肿瘤临床》2011年第6期357-360,共4页Chinese Journal of Clinical Oncology

基　　金：教育部新世纪优秀人才支持计划项目(编号:NCET-07-0615);国家自然科学基金(编号:30971136);天津市科技计划项目资助(编号:09JCZDJC17600)

摘　　要：小RNA(microRNA,miRNA)是近年发现的一类内源性非编码单链RNA,在转录后水平对基因表达发挥负调控作用,参与细胞生长、发育、凋亡等重要生物过程。研究发现miRNA-21在肿瘤的发生发展过程中扮演着非常重要的角色,在不同类型肿瘤中的表达均出现明显上升,与肿瘤细胞的增殖、侵袭、血管的生成和抗药性等生物学行为相关。本文将从miRNA-21的表达与定位、对靶基因的调控以及对miRNA-21的转录调控等方面进行综述。MicroRNAs （mRNAs） are a class of endogenous small noncoding single-stranded RNAs that negatively regulate gene expression at the post-transcriptional level. MicroRNAs are involved in diverse biological processes, including development, cell differentiation and cell death. It was found that miRNA-21 played an important role in the course of oncogenesis. The expression of miRNA-21 is significantly upregulated in different kinds of solid tumors. It is involved in cell proliferation, cell invasiveness, angiogenesis and other biological behaviors. This review summarizes the current knowledge concerning the expression and location of miRNA-21 and the regulatory network related to miRNA-21 in cancer.

关 键 词：MIRNA-21 肿瘤 信号通路 转录 

分 类 号：R730.5[医药卫生—肿瘤]